MRI-based methods for quantification of the cerebral metabolic rate of oxygen.
| Autor: | Rodgers ZB; University of Pennsylvania Medical Center, Philadelphia, PA, USA Laboratory for Structural, Physiologic, and Functional Imaging, Department of Radiology, Philadelphia, PA, USA., Detre JA; University of Pennsylvania Medical Center, Philadelphia, PA, USA Center for Functional Neuroimaging, Department of Neurology, Philadelphia, PA, USA., Wehrli FW; University of Pennsylvania Medical Center, Philadelphia, PA, USA wehrli@mail.med.upenn.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2016 Jul; Vol. 36 (7), pp. 1165-85. Date of Electronic Publication: 2016 Apr 18. |
| DOI: | 10.1177/0271678X16643090 |
| Abstrakt: | The brain depends almost entirely on oxidative metabolism to meet its significant energy requirements. As such, the cerebral metabolic rate of oxygen (CMRO2) represents a key measure of brain function. Quantification of CMRO2 has helped elucidate brain functional physiology and holds potential as a clinical tool for evaluating neurological disorders including stroke, brain tumors, Alzheimer's disease, and obstructive sleep apnea. In recent years, a variety of magnetic resonance imaging (MRI)-based CMRO2 quantification methods have emerged. Unlike positron emission tomography - the current "gold standard" for measurement and mapping of CMRO2 - MRI is non-invasive, relatively inexpensive, and ubiquitously available in modern medical centers. All MRI-based CMRO2 methods are based on modeling the effect of paramagnetic deoxyhemoglobin on the magnetic resonance signal. The various methods can be classified in terms of the MRI contrast mechanism used to quantify CMRO2: T2*, T2', T2, or magnetic susceptibility. This review article provides an overview of MRI-based CMRO2 quantification techniques. After a brief historical discussion motivating the need for improved CMRO2 methodology, current state-of-the-art MRI-based methods are critically appraised in terms of their respective tradeoffs between spatial resolution, temporal resolution, and robustness, all of critical importance given the spatially heterogeneous and temporally dynamic nature of brain energy requirements. (© The Author(s) 2016.) |
| Databáze: | MEDLINE |
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