| Autor: |
Miner-Williams WM; 1Riddet Institute,Massey University,Private Bag 11-222,Palmerston North,New Zealand., Moughan PJ; 1Riddet Institute,Massey University,Private Bag 11-222,Palmerston North,New Zealand. |
| Jazyk: |
angličtina |
| Zdroj: |
Nutrition research reviews [Nutr Res Rev] 2016 Jun; Vol. 29 (1), pp. 40-59. Date of Electronic Publication: 2016 Apr 18. |
| DOI: |
10.1017/S0954422416000019 |
| Abstrakt: |
The intestinal epithelium of adult humans acts as a differentially permeable barrier that separates the potentially harmful contents of the lumen from the underlying tissues. Any dysfunction of this boundary layer that disturbs the homeostatic equilibrium between the internal and external environments may initiate and sustain a biochemical cascade that results in inflammation of the intestine. Key to such dysfunction are genetic, microbial and other environmental factors that, singularly or in combination, result in chronic inflammation that is symptomatic of inflammatory bowel disease (IBD). The aim of the present review is to assess the scientific evidence to support the hypothesis that defective transepithelial transport mechanisms and the heightened absorption of intact antigenic proinflammatory oligopeptides are important contributing factors in the pathogenesis of IBD. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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