Exposure to methylergonovine maleate as a cause of sirenomelia.

Autor: Cozzolino M; Department of Biomedical, Experimental and Clinical Sciences - Division of Obstetrics and Gynecology, University of Florence, Careggi University Hospital, Florence, Italy., Riviello C; Private Practice, Futura Diagnostica Medica, Firenze, Italy., Fichtel G; Service of Pathology, Hospital of Bolzano, Bolzano, Italy., Tommaso MD; Department of Biomedical, Experimental and Clinical Sciences - Division of Obstetrics and Gynecology, University of Florence, Careggi University Hospital, Florence, Italy.
Jazyk: angličtina
Zdroj: Birth defects research. Part A, Clinical and molecular teratology [Birth Defects Res A Clin Mol Teratol] 2016 Jul; Vol. 106 (7), pp. 643-7. Date of Electronic Publication: 2016 Apr 18.
DOI: 10.1002/bdra.23503
Abstrakt: Background: Sirenomelia is a rare, but deadly condition characterized by fusion of the lower limbs, lower spinal column defects, severe malformations of the urogenital and lower gastrointestinal tract, and an aberrant abdominal umbilical artery.
Methods: The two main hypotheses, not mutually exclusive, that have been advanced to explain the pathogenesis of sirenomelia are the blastogenetic theory and the vascular disruption theory.
Results: We describe a case of sirenomelia, probably associated with the use of methylergonovine maleate, an ergot alkaloid, during the first weeks of pregnancy.
Conclusion: On the basis of the mechanisms of vascular disruption and early administration of methylergonovine maleate at a critical stage of organogenesis, we conclude that exposure to methylergonovine maleate could be the cause of the development of sirenomelia. Birth Defects Research (Part A) 106:643-647, 2016. © 2016 Wiley Periodicals, Inc.
(© 2016 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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