| Autor: |
Dey I; Department of Physiology and Biophysics, Chicago Medical School, North Chicago, Illinois, USA., Shah K; Department of Physiology and Biophysics, Chicago Medical School, North Chicago, Illinois, USA., Bradbury NA; Department of Physiology and Biophysics, Chicago Medical School, North Chicago, Illinois, USA. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of genetic syndromes & gene therapy [J Genet Syndr Gene Ther] 2016 Feb; Vol. 7 (1). Date of Electronic Publication: 2016 Jan 30. |
| DOI: |
10.4172/2157-7412.1000284 |
| Abstrakt: |
The recent FDA approval of two drugs to treat the basic defect in cystic fibrosis has given hope to patients and their families battling this devastating disease. Over many years, with heavy financial investment from Vertex Pharmaceuticals and the Cystic Fibrosis Foundation, pre-clinical evaluation of thousands of synthetic drugs resulted in the production of Kalydeco and Orkambi. Yet, despite the success of this endeavor, many other compounds have been proposed as therapeutic agents in the treatment of CF. Of note, several of these compounds are naturally occurring, and are present in spices from the grocery store and over the counter preparations in health food stores. In this short review, we look at three such compounds, genistein, curcumin, and resveratrol, and evaluate the scientific support for their use as therapeutic agents in the treatment of patients with CF. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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