Relationship between QT Interval Length and Arterial Stiffness in Systemic Lupus Erythematosus (SLE): A Cross-Sectional Case-Control Study.

Autor: Rivera-López R; Cardiology Clinical Management Unit, Granada University Hospitals; Granada Institute of Biohealth Research.Granada. Spain., Jiménez-Jáimez J; Cardiology Clinical Management Unit, Granada University Hospitals; Granada Institute of Biohealth Research.Granada. Spain., Sabio JM; Systemic Autoinmune Diseases Unit. Department of Internal Medicine. Granada University Hospitals; Granada Institute of Biohealth Research.Granada. Spain., Zamora-Pasadas M; Systemic Autoinmune Diseases Unit. Department of Internal Medicine. Granada University Hospitals; Granada Institute of Biohealth Research.Granada. Spain., Vargas-Hitos JA; Systemic Autoinmune Diseases Unit. Department of Internal Medicine. Granada University Hospitals; Granada Institute of Biohealth Research.Granada. Spain., Martínez-Bordonado J; Systemic Autoinmune Diseases Unit. Department of Internal Medicine. Granada University Hospitals; Granada Institute of Biohealth Research.Granada. Spain., Navarrete-Navarrete N; Systemic Autoinmune Diseases Unit. Department of Internal Medicine. Granada University Hospitals; Granada Institute of Biohealth Research.Granada. Spain., Fernández RR; Intensive Care Unit. Serrania Hospital, Ronda (Málaga). Spain., Sanchez-Cantalejo E; Andalusian School of Public Health, Granada, Spain.; CIBER de Epidemiología y Salud Publica (CIBERESP), Madrid, Spain.; Instituto de Investigación Biosanitaria de Granada (Granada. ibs), Granada, Spain., Jiménez-Alonso J; Systemic Autoinmune Diseases Unit. Department of Internal Medicine. Granada University Hospitals; Granada Institute of Biohealth Research.Granada. Spain.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2016 Apr 11; Vol. 11 (4), pp. e0152291. Date of Electronic Publication: 2016 Apr 11 (Print Publication: 2016).
DOI: 10.1371/journal.pone.0152291
Abstrakt: Introduction and Objectives: The QT interval on the electrocardiogram has been shown to be longer in patients with systemic lupus erythematosus (SLE) compared to that of the general population. The clinical significance of this finding is unknown. The aim of this study was to assess the relationship between QT interval and subclinical atherosclerosis, measured by carotid-femoral pulse-wave velocity.
Material and Methods: 93 patients with SLE and 109 healthy women with similar basal characteristics were studied. All patients underwent a 12- lead electrocardiogram, and corrected QT interval (QTc) was measured using the Bazett's formula. The presence of atherosclerosis was evaluated by carotid-femoral pulse-wave velocity.
Results: Clinical basal characteristics were similar in both groups. QTc interval was 415 ± 21.4 milliseconds in all patients, and 407 ± 19.1 milliseconds in the control group (p = 0.007). There was a positive correlation between QTc interval and carotid-femoral pulse-wave velocity (r = 0.235; p = 0.02) in patients with SLE. This association was independent of hypertension and age in a multivariate analysis.
Conclusion: QTc interval measured by electrocardiogram is prolonged in SLE patients; it is related to subclinical atherosclerosis, measured by carotid-femoral pulse-wave velocity. This measure may help stratify risk in routine clinical practice and select the patients that might benefit from a more aggressive therapy in the prevention of cardiovascular events.
Databáze: MEDLINE
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