| Autor: |
Pençe S; Istanbul University Institute for Experimental Medical Research, Department of Molecular Medicine Istanbul Turkey sadrettin.pence@istanbul.edu.tr., Özbek E; Okmeydani Training and Research Hospital Department of Urology Istanbul Turkey., Ozan Tiryakioğlu N; Istanbul University Institute for Experimental Medical Research, Department of Molecular Medicine Istanbul Turkey., Ersoy Tunali N; Haliç University Department of Molecular Biology and Genetics Istanbul Turkey nagehanersoy@halic.edu.tr. |
| Jazyk: |
angličtina |
| Zdroj: |
Cellular and molecular biology (Noisy-le-Grand, France) [Cell Mol Biol (Noisy-le-grand)] 2016 Mar 20; Vol. 62 (3), pp. 25-30. Date of Electronic Publication: 2016 Mar 20. |
| Abstrakt: |
Analyses of differential miRNA expressions in tumor and normal tissues can identify specific miRNAs involved in cancer pathogenesis, which can then be used as diagnostic, therapeutic and prognostic biomarkers. In this respect, we aimed to investigate expression levels of seven CpG island-harboring miRNAs in 50 paired UBC tissues by qRT-PCR. miR-21 and miR-155 were found to be significantly upregulated, and miR-23b, miR-126, miR-129-5p, miR-143a and miR-218-5p were downregulated. ROC analysis indicated miR-155 as the most promising candidate for discrimination of tumors from healthy tissue, and miR-23b for the discrimination of early stage from late stage tumors. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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