The effects of alcohol mixed with energy drink (AMED) on subjective intoxication and alertness: results from a double-blind placebo-controlled clinical trial.

Autor: van de Loo AJ; Division of Pharmacology, Utrecht University, Utrecht, The Netherlands., van Andel N; Division of Pharmacology, Utrecht University, Utrecht, The Netherlands., van Gelder CA; Division of Pharmacology, Utrecht University, Utrecht, The Netherlands., Janssen BS; Division of Pharmacology, Utrecht University, Utrecht, The Netherlands., Titulaer J; Division of Pharmacology, Utrecht University, Utrecht, The Netherlands., Jansen J; Division of Pharmacology, Utrecht University, Utrecht, The Netherlands., Verster JC; Division of Pharmacology, Utrecht University, Utrecht, The Netherlands.; Swinburne University, Melbourne, Australia.
Jazyk: angličtina
Zdroj: Human psychopharmacology [Hum Psychopharmacol] 2016 May; Vol. 31 (3), pp. 200-5. Date of Electronic Publication: 2016 Apr 06.
DOI: 10.1002/hup.2529
Abstrakt: Objective: The purpose of this double blind placebo controlled study was to examine if specific effects on subjective intoxication and alertness-sleepiness ratings could be demonstrated after consuming alcohol mixed with energy drink (AMED) when compared to consuming alcohol only (AO).
Methods: 56 healthy volunteers rated their subjective intoxication on a scale ranging from 0 (sober) to 10 (highly intoxicated) at baseline, breath alcohol concentration (BAC) of 0%, and at BAC 0.08%, 0.05%, and 0.02%. Alertness-sleepiness was assessed with the Karolinska sleepiness scale. Scores of the AMED and AO condition, at each BAC level, were compared.
Results: Subjective intoxication for AMED and AO did not differ significantly from each other at any BAC level, except for BAC 0.02%. A significant increase in sleepiness scores was found in the AO condition, whereas scores remained stable in the AMED condition. Sleepiness scores at BAC0.08% and 0.05% were significantly lower after AMED when compared to AO. However, the observed differences between AMED and AO were small and have no clinical relevance.
Conclusion: Mixing alcohol with energy drink had no overall masking effect on subjective intoxication caused by alcohol, nor had a relevant effect on subjective alertness-sleepiness ratings. Copyright © 2016 John Wiley & Sons, Ltd.
(Copyright © 2016 John Wiley & Sons, Ltd.)
Databáze: MEDLINE
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