| Autor: |
Gonçalves Junior R; Postgraduate Program in Dentistry, Universidade Federal Fluminense, Niterói, RJ, Brazil., Pinheiro Ada R; Dental Clinical Department, Universidade Federal Fluminense, Niterói, RJ, Brazil., Schoichet JJ; Oral Implantology Post-graduation, Universidade Federal Fluminense, Niterói, RJ, Brazil., Nunes CH; Oral Implantology Post-graduation, Universidade Federal Fluminense, Niterói, RJ, Brazil., Gonçalves R; Oral Implantology Post-graduation, Universidade Federal Fluminense, Niterói, RJ, Brazil., Bonato LL; Postgraduate Program in Dentistry, Universidade Federal Fluminense, Niterói, RJ, Brazil., Quinelato V; Postgraduate Program in Dentistry, Universidade Federal Fluminense, Niterói, RJ, Brazil., Antunes LS; Departament of Specific Formation, School of Dentistry, Universidade Federal Fluminense, Nova Friburgo, RJ, Brazil., Küchler EC; Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil., Lobo J; Clinical Research Unit and Biology Institute, Universidade Federal Fluminense, Niterói, RJ, Brazil., Villas-Bôas Rde M; Postgraduate Program in Dentistry, Universidade Federal Fluminense, Niterói, RJ, Brazil., Vieira AR; Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Granjeiro JM; Quality and Technology, National Institute of Metrology, Rio de Janeiro, RJ, Brazil., Casado PL; Postgraduate Program in Dentistry, Universidade Federal Fluminense, Niterói, RJ, Brazil. |
| Abstrakt: |
Subjects susceptible to chronic periodontitis (CP) show a high risk for the development of periimplantitis (PI). Both diseases are multifactorial, presenting similarities in their pathophysiology and polygenic profile. MMP-13 (matrix metalloproteinases 13/ collagenase 3) is a collagenolytic enzyme, which expression is induced by TGF beta 3 (transforming growth factor type 3) in human gingival fibroblasts and inhibited by TIMP-2 (tissue inhibitor of metalloproteinase type 2). The aim of this study was to investigate the occurrence of periimplantitis (PI) in subjects with history of chronic periodontitis (CP) and polymorphisms frequency in MMP13, TIMP2 and TGFB3 genes. One hundred and sixty-three volunteers received dental implant placement were submitted to oral and radiographic examination in order to identify past history of CP or presence of PI. Volunteers were divided into 4 groups: Control (without PI and CP, n=72), CP (with CP and without PI, n=28), PI (with PI and without CP, n=28) and diseased (with CP and PI, n=35). The chi-square test correlated genotypes in specific regions of MMP13 (rs2252070), TIMP2 (rs7501477) and TGFB3 (rs2268626) genes, considering the interaction between CP and PI. The results showed that volunteers with CP had 3.2 times more susceptibility to develop PI (p=0.0004) compared to those without CP. No significant association was observed in MMP13, TIMP2 and TGFB3 genes with CP or PI. CP is a risk factor to develop PI, however, there is no association of both diseases with polymorphisms in the MMP13, TIMP2 and TGFB3 genes. |
