DNA Equation of State: In Vitro vs In Viro.

Autor:	Podgornik R; Department of Physics, University of Massachusetts , Amherst, Massachusetts 01003, United States.; Department of Theoretical Physics, Jožef Stefan Institute , SI-1000 Ljubljana, Slovenia.; Department of Physics, Faculty of Mathematics and Physics, University of Ljubljana , SI-1000 Ljubljana, Slovenia., Aksoyoglu MA; Department of Physics, University of Massachusetts , Amherst, Massachusetts 01003, United States., Yasar S; Department of Physics, University of Massachusetts , Amherst, Massachusetts 01003, United States., Svenšek D; Department of Physics, Faculty of Mathematics and Physics, University of Ljubljana , SI-1000 Ljubljana, Slovenia., Parsegian VA; Department of Physics, University of Massachusetts , Amherst, Massachusetts 01003, United States.
Jazyk:	angličtina
Zdroj:	The journal of physical chemistry. B [J Phys Chem B] 2016 Jul 07; Vol. 120 (26), pp. 6051-60. Date of Electronic Publication: 2016 Apr 25.
DOI:	10.1021/acs.jpcb.6b02017
Abstrakt:	We formulate a continuum approach to the equation of state (density dependence of osmotic pressure) of bulk DNA and encapsidated DNA, as well as review the phase diagram of DNA in the regime of densities relevant for DNA packing in bacteriophages. We derive the first integral of the equilibrium equations that connects the behavior of DNA in the bulk and in nanoscale enclosures, and we delineate the changes wrought upon the mesophase equilibria of encapsidated DNA. We show how multiphase equilibria and complicated spatial distribution of DNA density and orientation can emerge due to the curvature contribution to the DNA osmotic pressure within the capsid.
Databáze:	MEDLINE
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