Metformin-Induced Fixed-Drug Eruption Confirmed by Multiple Exposures.
Autor: | Steber CJ; Levine College of Health Sciences, Wingate University, Wingate, NC, USA., Perkins SL; College of Pharmacy and Health Sciences, Campbell University, Buies Creek, NC, USA., Harris KB; Levine College of Health Sciences, Wingate University, Wingate, NC, USA. |
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Jazyk: | angličtina |
Zdroj: | The American journal of case reports [Am J Case Rep] 2016 Apr 08; Vol. 17, pp. 231-4. Date of Electronic Publication: 2016 Apr 08. |
DOI: | 10.12659/ajcr.896424 |
Abstrakt: | Background: A fixed-drug eruption (FDE) is a reaction characterized by cutaneous lesions that appear due to exposure to a particular drug. Barbiturates, carbamazepine, sulfamethoxazole, and tetracyclines have all been associated with causation of FDEs. Although these drugs are more commonly associated with FDEs, any introduction of a medication has the potential to result in a FDE. Metformin, a commonly used medication to improve glycemic control, has been reported to cause dermatologic reactions in some case reports, but only a single previously documented case report discusses the potential of metformin-associated FDE. Case Report: We describe a 56-year-old woman who developed a FDE with multiple exposures to metformin. Upon each exposure, small, round, erythematic lesions developed on the palms of the hands and soles of the feet; these lesions resolved each time after discontinuation of metformin. According to the Naranjo scale, there is a definite association between metformin and FDE in this case (score of 8). Conclusions: This report contributes to the limited documented literature on metformin-induced FDE. Clinicians should be made aware of possible FDEs associated with this commonly used medication. |
Databáze: | MEDLINE |
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