Interactions of Some Divalent Metal Ions with Thymine and Uracil Thiosemicarbazide Derivatives.

Autor: Hammud HH; a Department of Chemistry, Faculty of Science , King Faisal University , Al-Ahsa , Saudi Arabia., El-Dakdouki MH; b Department of Chemistry, Faculty of Science , Beirut Arab University , Debbieh , Lebanon., Sonji N; b Department of Chemistry, Faculty of Science , Beirut Arab University , Debbieh , Lebanon., Sonji G; b Department of Chemistry, Faculty of Science , Beirut Arab University , Debbieh , Lebanon., Bouhadir KH; c Department of Chemistry, Faculty of Arts and Sciences , American University of Beirut , Beirut , Lebanon.
Jazyk: angličtina
Zdroj: Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2016 May 03; Vol. 35 (5), pp. 259-76. Date of Electronic Publication: 2016 Apr 06.
DOI: 10.1080/15257770.2016.1143558
Abstrakt: The study of interactions between metal ions and nucleobases, nucleosides, nucleotides, or nucleic acids has become an active research area in chemical, biological, and therapeutic fields. In this respect, the coordination behavior of nucleobase derivatives to transition metals was studied in order to get a better understanding about DNA-metal interactions in in vitro and in vivo systems. Two nucleobase derivatives, 3-benzoyl-1-[3-(thymine-1-yl)propamido]thiourea and 3-benzoyl-1-[3-(uracil-1-yl)propamido]thiourea, were synthesized and their dissociation constants were determined at different temperatures and 0.3 ionic strength. Potentiometric studies were carried out on the interaction of the derivatives towards some divalent metals in 50% v/v ethanol-water containing 0.3 mol.dm(-3) KCl, at five different temperatures. The formation constants of the metal complexes for both ligands follow the order: Cu(2+) > Ni(2+) > Co(2+) > Zn(2+) > Pb(2+) > Cd(2+) > Mn(2+). The thermodynamic parameters were estimated; the complexation process has been found to be spontaneous, exothermic, and entropically favorable.
Databáze: MEDLINE
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