Obstructive sleep apnoea is associated with myocardial injury in patients with refractory angina.

Autor:	Geovanini GR; Sleep Laboratory, Pulmonary Division, Heart Institute (InCor), University of São Paulo (USP), Sao Paulo, Brazil., Pereira AC; Laboratory of Genetics and Molecular Cardiology, InCor, USP, Sao Paulo, Brazil., Gowdak LH; Refractory Angina Research Group, InCor, USP, Sao Paulo, Brazil., Dourado LO; Refractory Angina Research Group, InCor, USP, Sao Paulo, Brazil., Poppi NT; Refractory Angina Research Group, InCor, USP, Sao Paulo, Brazil., Venturini G; Laboratory of Genetics and Molecular Cardiology, InCor, USP, Sao Paulo, Brazil., Drager LF; Sleep Laboratory, Pulmonary Division, Heart Institute (InCor), University of São Paulo (USP), Sao Paulo, Brazil Hypertension Unit, InCor, USP, Sao Paulo, Brazil., Lorenzi-Filho G; Sleep Laboratory, Pulmonary Division, Heart Institute (InCor), University of São Paulo (USP), Sao Paulo, Brazil.
Jazyk:	angličtina
Zdroj:	Heart (British Cardiac Society) [Heart] 2016 Aug 01; Vol. 102 (15), pp. 1193-9. Date of Electronic Publication: 2016 Apr 05.
DOI:	10.1136/heartjnl-2015-309009
Abstrakt:	Objective: To investigate the association between obstructive sleep apnoea (OSA) severity with markers of overnight myocardial injury in patients with refractory angina. Methods: Patients with refractory angina were characterised clinically and they underwent ischaemia imaging stress tests by single-photon emission computed tomography (SPECT) and/or cardiac MRI. The patients were admitted to the hospital, remained under resting conditions for blood determination of high-sensitivity cardiac troponin T (hs-cTnT) at 14:00, 22:00 and after overnight polysomnography at 7:00. Results: We studied 80 consecutive patients (age: 62±10 years; male: 66%; body mass index (BMI): 29.5±4 kg/m(2)) with well-established diagnosis of refractory angina. The mean apnoea-hypopnoea index (AHI) was 37±29 events/h and OSA (AHI >15 events/h) was present in 75% of the population. Morning detectable hs-cTnT and above 99th percentile was present in 88% and 36% of the population, respectively. Patients in the first to third quartiles of OSA severity did not have circadian variation of hs-cTnT. In contrast, patients in the fourth quartile (AHI ≥51 events/h) had a circadian variation of hs-cTnT with a morning peak of hs-cTnT that was two times higher than that in the remaining population (p=0.02). The highest quartile of OSA severity remained associated with the highest quartile of hs-cTnT (p=0.028) in multivariate analysis. Conclusion: Very severe OSA is common and independently associated with overnight myocardial injury in patients with refractory angina. (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/)
Databáze:	MEDLINE
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