Inadequate critical appraisal of studies in systematic reviews of time to diagnosis.

Autor: Launay E; Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), Center for Epidemiology and Statistics Sorbonne Paris Cité, Paris Descartes University, 53 avenue de l'observatoire, 75014 Paris, France; CHU de Nantes, Hôpital Mère-Enfant, Services de pédiatrie générale et d'urgences pédiatriques, 7 quai Moncousu, 44000 Nantes, France. Electronic address: elise.launay@chu-nantes.fr., Cohen JF; Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), Center for Epidemiology and Statistics Sorbonne Paris Cité, Paris Descartes University, 53 avenue de l'observatoire, 75014 Paris, France; Service de pédiatrie générale, Hôpital Necker-Enfants malades, 149 rue de Sèvres, 75015 Paris, France; AP-HP, Paris, France; Université Paris Descartes, Paris, France., Morfouace M; Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), Center for Epidemiology and Statistics Sorbonne Paris Cité, Paris Descartes University, 53 avenue de l'observatoire, 75014 Paris, France; Service de pédiatrie générale, Hôpital Necker-Enfants malades, 149 rue de Sèvres, 75015 Paris, France; AP-HP, Paris, France; Université Paris Descartes, Paris, France., Gras-Le Guen C; CHU de Nantes, Hôpital Mère-Enfant, Services de pédiatrie générale et d'urgences pédiatriques, 7 quai Moncousu, 44000 Nantes, France., Ravaud P; Inserm UMR 1153, METHODS Team, Center for Epidemiology and Statistics Sorbonne Paris Cité, Paris Descartes University, APHP, ​hôpital Hotel Dieu, 1 place du parvis Notre Dame, 75004 Paris, France., Chalumeau M; Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), Center for Epidemiology and Statistics Sorbonne Paris Cité, Paris Descartes University, 53 avenue de l'observatoire, 75014 Paris, France; Service de pédiatrie générale, Hôpital Necker-Enfants malades, 149 rue de Sèvres, 75015 Paris, France; AP-HP, Paris, France; Université Paris Descartes, Paris, France.
Jazyk: angličtina
Zdroj: Journal of clinical epidemiology [J Clin Epidemiol] 2016 Oct; Vol. 78, pp. 43-51. Date of Electronic Publication: 2016 Mar 30.
DOI: 10.1016/j.jclinepi.2016.03.013
Abstrakt: Objective: To analyze tools used to critically appraise primary studies included in systematic reviews (SRs) of time to diagnosis (TTD).
Study Design and Setting: We systematically searched MEDLINE via PubMed and Web of Science for SRs of TTD published up to the end of February 2015; we identified and characterized tools used for critical appraisal and classified their items.
Results: From 1,936 articles identified, we included 45 SRs that aimed to summarize the available information on the length (n = 16), determinants (n = 31), and/or consequences (n = 14) of TTD. For the 23 SRs (51%) reporting a critical appraisal process, 21 different tools were used, with 232 items assessing quality of reporting (64%), risk of bias or threats to generalizability (43%), statistical issues (5%), and/or an unclear domain (0.5%); 11% were specific to TTD issues. Overall, 36% of the 45 SRs assessed risk of bias and/or threats to generalizability.
Conclusion: Assessment of risk of bias and threats to generalizability in primary studies included in SRs of TTD is infrequent, nonstandardized and rarely concerns TTD study specificities. These findings highlight the need for guidance on critical appraisal of studies of TTD.
(Copyright © 2016 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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