Visceral adiposity is associated with cytokines and decrease in lung function in women with persistent asthma.

Autor:	Capelo AV; Gaffrée and Guinle Hospital from Federal University of the State of Rio de Janeiro (UNIRIO), HUGG, Medical, Rua Mariz e Barros, 775, Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: albertinacapelo@hotmail.com., da Fonseca VM; Fernandes Figueira Institute from FIOCRUZ, IFF, Education, Av. Rui Barbosa, 716, Rio de Janeiro, Rio de Janeiro 22250-020, Brazil., Peixoto MV; Fernandes Figueira Institute from FIOCRUZ, IFF, Education, Av. Rui Barbosa, 716, Rio de Janeiro, Rio de Janeiro 22250-020, Brazil., de Carvalho SR; Gaffrée and Guinle Hospital from Federal University of the State of Rio de Janeiro (UNIRIO), HUGG, Medical, Rua Mariz e Barros, 775, Rio de Janeiro, Rio de Janeiro, Brazil., Azevedo CM; Gaffrée and Guinle Hospital from Federal University of the State of Rio de Janeiro (UNIRIO), HUGG, Medical, Rua Mariz e Barros, 775, Rio de Janeiro, Rio de Janeiro, Brazil., Elsas MI; Microbiology Institute from Federal University of Rio de Janeiro (UFRJ), Rua Rodolpho Paulo Roco, 255, Rio de Janeiro, Brazil., Marques B; Microbiology Institute from Federal University of Rio de Janeiro (UFRJ), Rua Rodolpho Paulo Roco, 255, Rio de Janeiro, Brazil.
Jazyk:	angličtina
Zdroj:	Revista portuguesa de pneumologia [Rev Port Pneumol (2006)] 2016 Sep-Oct; Vol. 22 (5), pp. 255-61. Date of Electronic Publication: 2016 Mar 29.
DOI:	10.1016/j.rppnen.2016.02.005
Abstrakt:	Unlabelled: Abdominal obesity is associated with a risk of cardiovascular diseases, metabolic syndrome and decreased lung function. However, it is not known whether asthma control is influenced by the accumulation of adipose tissue in the various abdominal compartments. Objective: To determine associations among abdominal adiposity distribution, asthma control, lung function and cytokines in women. Methods and Design: In this cross-sectional study of asthmatic women, data on demographic variables, comorbid conditions, disease history, anthropometric and spirometric measurements were collected. Subcutaneous (SAT) and visceral (VAT) adipose tissues were measured by ultrasound, and the steatosis level was obtained. Asthma control was assessed according to Global Initiative for Asthma (GINA) criteria. Atopy was defined on the basis of allergen-specific Immunoglobulin E and/or skin prick testing. Cytokine levels were determined using enzyme-linked immunosorbant assays (ELISAs). Results: Eighty-three asthmatic women were included, 37% of whom had uncontrolled asthma. After controlling for variables, a negative association between asthma control and VAT and the VAT/SAT ratio was observed. VAT was negatively associated with respiratory parameters after controlling for explanatory variables. In an adjusted model, body mass index (BMI) and SAT were inversely associated with the adiponectin serum level and VAT was associated with the interleukin 6 level. In conclusion, visceral obesity was negatively associated with asthma control and lung function; and positively associated with increased levels of interleukin 6 in women. We hypothesize that women should be studied as a separate group, and we suggest further studies with a control group to know if the uncontrolled asthmatic group is directly affected by visceral adipose inflammatory markers. (Copyright © 2016 Sociedade Portuguesa de Pneumologia. Published by Elsevier España, S.L.U. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu