AMPK activators: mechanisms of action and physiological activities.

Autor:	Kim J; Depatment of Oral Biochemistry and Molecular Biology, School of Dentistry, Kyung Hee University, Seoul, Korea., Yang G; Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul, Korea., Kim Y; Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul, Korea., Kim J; Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul, Korea., Ha J; Department of Biochemistry and Molecular Biology, Graduate School, Kyung Hee University, Seoul, Korea.
Jazyk:	angličtina
Zdroj:	Experimental & molecular medicine [Exp Mol Med] 2016 Apr 01; Vol. 48, pp. e224. Date of Electronic Publication: 2016 Apr 01.
DOI:	10.1038/emm.2016.16
Abstrakt:	AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis, which coordinates metabolic pathways and thus balances nutrient supply with energy demand. Because of the favorable physiological outcomes of AMPK activation on metabolism, AMPK has been considered to be an important therapeutic target for controlling human diseases including metabolic syndrome and cancer. Thus, activators of AMPK may have potential as novel therapeutics for these diseases. In this review, we provide a comprehensive summary of both indirect and direct AMPK activators and their modes of action in relation to the structure of AMPK. We discuss the functional differences among isoform-specific AMPK complexes and their significance regarding the development of novel AMPK activators and the potential for combining different AMPK activators in the treatment of human disease.
Databáze:	MEDLINE
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