[The efficacy of pharmacological preconditioning in carotid endarterectomy].

Autor:	Kuznetsov MP; Pirogov Russian National Research Medical University, Moscow., Fedin AI; Pirogov Russian National Research Medical University, Moscow., Karalkin AV; Pirogov City Hospital #1, Moscow., Frolov KB; Pirogov City Hospital #1, Moscow., Kunitsin NV; Pirogov City Hospital #1, Moscow., Yumin SM; Pirogov Russian National Research Medical University, Moscow., Kholopova EA; Pirogov Russian National Research Medical University, Moscow., Knyazev AV; Pirogov Russian National Research Medical University, Moscow, Pirogov City Hospital #1, Moscow.
Jazyk:	ruština
Zdroj:	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2016; Vol. 116 (2), pp. 34-41.
DOI:	10.17116/jnevro20161162134-41
Abstrakt:	Objective: To assess the efficacy of pharmacological preconditioning with actovegin in carotid endarterectomy. Material and Methods: The study was based on the results of surgical treatment of 80 patients with hemodynamically significant uni- and bilateral lesions of carotid arteries. Half of the patients was operated immediately and others after pharmacological preconditioning with actovegin in dose of 1200 mg/daily during 1,5 months. Results: Pharmacological preconditioning with actovegin increased the cerebral perfusion determined with one-photon emission computed tomography that improved significantly results of the surgery. There were significant changes in patient's state 7 days and 6 months after surgery. The improvement was correlated with the less number of asymptotic post-surgery ischemic strokes in different brain areas. Conclusion: A positive role of pharmacological preconditioning with actovegin in surgical treatment of carotid artery stenosis has been demonstrated.
Databáze:	MEDLINE
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