Genetic variation in SLC17A7 promoter associated with response to sport-related concussions.

Autor:	Madura SA; a Department of Kinesiology , Temple University , Philadelphia , PA , USA., McDevitt JK; a Department of Kinesiology , Temple University , Philadelphia , PA , USA., Tierney RT; a Department of Kinesiology , Temple University , Philadelphia , PA , USA., Mansell JL; a Department of Kinesiology , Temple University , Philadelphia , PA , USA., Hayes DJ; a Department of Kinesiology , Temple University , Philadelphia , PA , USA., Gaughan JP; b Biostatistics Consulting Center , Philadelphia , PA , USA., Krynetskiy E; c Temple University School of Pharmacy , Philadelphia , PA , USA.
Jazyk:	angličtina
Zdroj:	Brain injury [Brain Inj] 2016; Vol. 30 (7), pp. 908-13. Date of Electronic Publication: 2016 Mar 30.
DOI:	10.3109/02699052.2016.1146958
Abstrakt:	Objective: To determine the association of the single nucleotide polymorphism (SNP) rs74174284 within SLC17A7 promoter with concussion severity or duration. Design: A between-subjects design was utilized. Methods: Saliva samples and concussion severity and duration data were collected from 40 athletes diagnosed with a sport-related concussion by a physician, utilizing a standardized concussion assessment protocol. DNA was extracted, estimated and genotyped. Results: An association was found between the dominant genetic model (CC vs GG + GC; p = 0.0179) and recovery, where those carrying the minor allele were 6.33-times more likely to experience prolonged recovery rates. Within the ImPACT assessment, those carrying the CC genotype (33.38 ± 10.15, p = 0.01) had worse motor speed scores upon initial assessment compared to both heterozygous (CG) and homozygous (GG) genotypes (41.59 ± 7.39). Conclusions: This study was the first to demonstrate an association between genetic polymorphism at rs7417284 SNP in the promoter region of the SLC17A7 gene and concussion severity and duration. Based upon these findings, rs74174284 is a potential predictive genetic marker for identifying athletes who are more susceptible for altered recovery times and worse motor speed ImPACT scores after sport-related concussion.
Databáze:	MEDLINE
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