| Autor: |
Nayak S; aCenter for Substance Abuse Research bDepartment of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA., Roberts A, Bires K, Tallarida CS, Kim E, Wu M, Rawls SM |
| Jazyk: |
angličtina |
| Zdroj: |
Behavioural pharmacology [Behav Pharmacol] 2016 Sep; Vol. 27 (6), pp. 556-8. |
| DOI: |
10.1097/FBP.0000000000000236 |
| Abstrakt: |
Planarians spend less time in light versus dark environments. We hypothesized that planarians withdrawn from cocaine or ethanol would spend even less time in the light than drug-naive planarians and that a benzodiazepine would inhibit this response. Planarians pretreated in cocaine or ethanol were placed at the midline of a Petri dish containing spring water that was split evenly into dark and light compartments. Planarians withdrawn from cocaine (1, 10, 100 μmol/l) or ethanol (0.01%) spent less time in the light compartment than water controls; however, this withdrawal response to cocaine (100 μmol/l) or ethanol (0.01%) was abolished by clorazepate (0-100 μmol/l). These data suggest that planarians, similar to rodents, show benzodiazepine-sensitive, anxiogenic-like responses during cocaine or alcohol withdrawal. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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