Direct Photocontrol of Peptidomimetics: An Alternative to Oxygen-Dependent Photodynamic Cancer Therapy.

Autor: Babii O; Institute of Organic Chemistry (IOC), Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 6, 76131, Karlsruhe, Germany., Afonin S; Institute of Biological Interfaces (IBG-2), KIT, POB 3640, 76021, Karlsruhe, Germany., Garmanchuk LV; Institute of Biology, TSNUK, prosp. Hlushkova 2, 03022, Kyiv, Ukraine., Nikulina VV; Institute of Biology, TSNUK, prosp. Hlushkova 2, 03022, Kyiv, Ukraine., Nikolaienko TV; Institute of Biology, TSNUK, prosp. Hlushkova 2, 03022, Kyiv, Ukraine., Storozhuk OV; Institute of Biology, TSNUK, prosp. Hlushkova 2, 03022, Kyiv, Ukraine., Shelest DV; Institute of Biology, TSNUK, prosp. Hlushkova 2, 03022, Kyiv, Ukraine., Dasyukevich OI; Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine (NASU), vul. Vasylkivska 45, 03022, Kyiv, Ukraine., Ostapchenko LI; Institute of Biology, TSNUK, prosp. Hlushkova 2, 03022, Kyiv, Ukraine., Iurchenko V; Enamine Ltd., vul. Matrosova 23, 01103, Kyiv, Ukraine., Zozulya S; Enamine Ltd., vul. Matrosova 23, 01103, Kyiv, Ukraine., Ulrich AS; Institute of Organic Chemistry (IOC), Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 6, 76131, Karlsruhe, Germany. Anne.Ulrich@kit.edu.; Institute of Biological Interfaces (IBG-2), KIT, POB 3640, 76021, Karlsruhe, Germany. Anne.Ulrich@kit.edu., Komarov IV; Institute of High Technologies (IHT), Taras Shevchenko National University of Kyiv (TSNUK), vul. Volodymyrska 60, 01601, Kyiv, Ukraine. ik214@yahoo.com.
Jazyk: angličtina
Zdroj: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2016 Apr 25; Vol. 55 (18), pp. 5493-6. Date of Electronic Publication: 2016 Mar 30.
DOI: 10.1002/anie.201600506
Abstrakt: Conventional photodynamic treatment strategies are based on the principle of activating molecular oxygen in situ by light, mediated by a photosensitizer, which leads to the generation of reactive oxygen species and thereby causes cell death. A diarylethene-derived peptidomimetic is presented that is suitable for photodynamic cancer therapy without any involvement of oxygen. This light-sensitive molecule is not a mediator but is itself the cytotoxic agent. As a derivative of the cyclic amphiphilic peptide gramicidin S, the peptidomimetic exists in two thermally stable photoforms that are interconvertible by light of different wavelengths. The isomer generated by visible light shows much stronger toxicity against tumor cells than the UV-generated isomer. First in vivo applications are demonstrated on a tumor animal model to illustrate how the peptidomimetic can be administered in the less toxic form and then activated locally in a solid tumor by visible light.
(© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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