Clinical presentation, treatment and outcome in 31 dogs with presumed primary colorectal lymphoma (2001-2013).

Autor: Desmas I; Royal veterinary College, Hatfield, UK., Burton JH; Flint Animal Cancer Center, Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA., Post G; The Veterinary Cancer Center, Norwalk, CT, USA., Kristal O; Chavat Daat Veterinary Speciality Center, Beit Berl, Israel., Gauthier M; Mississauga Oakville Veterinary Emergency Hospital and Referral Services, Oakville, ON, Canada., Borrego JF; School of Veterinary Medicine, University of Madison-Wisconsin, Madison, WI, USA., Di Bella A; Vets Now Referrals, Medicine Service, Glasgow, UK., Lara-Garcia A; Royal veterinary College, Hatfield, UK.
Jazyk: angličtina
Zdroj: Veterinary and comparative oncology [Vet Comp Oncol] 2017 Jun; Vol. 15 (2), pp. 504-517. Date of Electronic Publication: 2016 Mar 29.
DOI: 10.1111/vco.12194
Abstrakt: The objective of this multicentre retrospective study was to describe clinical presentation, treatment and outcome and to determine prognostic factors for dogs with presumed primary colorectal lymphoma (PCRL). A total of 31 dogs were included. The predominant features of PCRL were high grade (n = 18) and immunophenotype B (n = 24). Most dogs were substage b (n = 25) with higher prevalence of haematochezia (n = 20). One dog had surgery only. Thirty dogs received chemotherapy; amongst them 13 had surgery or radiotherapy. Progression free survival (PFS) was 1318 days and disease-related median survival time (MST) was 1845 days. Fourteen dogs were alive at the end of the study with a median follow-up time of 684 days (3-4678 days). Younger dogs had longer PFS (P = 0.031) and disease-related MST (P = 0.01). Presence of haematochezia corresponded with longer PFS (P = 0.02). Addition of local treatment to chemotherapy did not significantly improve the outcome (P = 0.584). Canine PCRL has considerably longer PFS and MST than other forms of non-Hodgkin's lymphoma.
(© 2016 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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