Sex Differences in High Sensitivity C-Reactive Protein in Subjects with Risk Factors of Metabolic Syndrome.

Autor:	Garcia VP; Departamento de Fisiologia e Farmacologia, Laboratório de Ciências do Exercício, Universidade Federal Fluminense, Niterói, RJ, Brazil., Rocha HN; Departamento de Fisiologia e Farmacologia, Laboratório de Ciências do Exercício, Universidade Federal Fluminense, Niterói, RJ, Brazil., Sales AR; Instituto do Coração, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil., Rocha NG; Departamento de Fisiologia e Farmacologia, Laboratório de Ciências do Exercício, Universidade Federal Fluminense, Niterói, RJ, Brazil., da Nóbrega AC; Departamento de Fisiologia e Farmacologia, Laboratório de Ciências do Exercício, Universidade Federal Fluminense, Niterói, RJ, Brazil.
Jazyk:	English; Portuguese
Zdroj:	Arquivos brasileiros de cardiologia [Arq Bras Cardiol] 2016 Mar; Vol. 106 (3), pp. 182-7.
DOI:	10.5935/abc.20160027
Abstrakt:	Background: Metabolic syndrome (MetS) is associated with a higher risk of all-cause mortality. High-sensitivity C-reactive protein (hsCRP) is a prototypic marker of inflammation usually increased in MetS. Women with MetS-related diseases present higher hsCRP levels than men with MetS-related diseases, suggesting sex differences in inflammatory markers. However, it is unclear whether serum hsCRP levels are already increased in men and/or women with MetS risk factors and without overt diseases or under pharmacological treatment. Objective: To determine the impact of the number of MetS risk factors on serum hsCRP levels in women and men. Methods One hundred and eighteen subjects (70 men and 48 women; 36 ± 1 years) were divided into four groups according to the number of MetS risk factors: healthy group (CT; no risk factors), MetS ≤ 2, MetS = 3, and MetS ≥ 4. Blood was drawn after 12 hours of fasting for measurement of biochemical variables and hsCRP levels, which were determined by immunoturbidimetric assay. Results: The groups with MetS risk factors presented higher serum hsCRP levels when compared with the CT group (p < 0.02). There were no differences in hsCRP levels among groups with MetS risk factors (p > 0.05). The best linear regression model to explain the association between MetS risk factors and hsCRP levels included waist circumference and HDL cholesterol (r = 0.40, p < 0.01). Women with MetS risk factors presented higher hsCRP levels when compared with men (p sex < 0.01). Conclusions: Despite the absence of overt diseases and pharmacological treatment, subjects with MetS risk factors already presented increased hsCRP levels, which were significantly higher in women than men at similar conditions.
Databáze:	MEDLINE
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