| Autor: |
Schuster RK; Central Veterinary Research Laboratory, Dubai, United Arab Emirates., Mustafa MB; Veterinary Services Section, Dubai Municipality, Dubai, United Arab Emirates., Baskar JV; Central Veterinary Research Laboratory, Dubai, United Arab Emirates., Rosentel J; Merial, Inc., Duluth, GA, 30096, USA., Chester ST; Merial, Inc., Duluth, GA, 30096, USA., Knaus M; Merial GmbH, Kathrinenhof Research Center, 83101, Rohrdorf, Germany. martin.knaus@merial.com. |
| Abstrakt: |
Cats are host to dipylidiid cestodes of the genera Diplopylidium, Dipylidium and Joyeuxiella. Broadline(®), a topical broad-spectrum combination parasiticide containing fipronil (8.3 % w/v), (S)-methoprene (10 % w/v), eprinomectin (0.4 % w/v) and the cestocide praziquantel (8.3 % w/v), has previously been shown to be efficacious against Dipylidium caninum and Diplopylidium spp. in cats. To evaluate its efficacy against Joyeuxiella species, a blinded clinical efficacy study was conducted according to GCP. All cats had evidence for naturally acquired dipylidiid cestode infection as confirmed by pre-treatment examination. Cats were allocated randomly to two groups of 13 cats each based on bodyweight: Control (untreated) and Broadline(®) at 0.12 mL/kg bodyweight administered once topically. Based on the comparison of helminth counts in the treated and untreated cats seven days post treatment, Broadline(®) demonstrated >99 % efficacy (p < 0.01) against mature J. fuhrmanni and J. pasqualei, with 11 and 13 of the untreated cats harbouring 1 to 102 or 2 to 95 cestodes, respectively. In addition, parasite counts indicated 95.9 % efficacy (p = 0.006) against the rictularoid nematode Pterygodermatites cahirensis. |
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