Molecular mechanism of modulation of nociceptive neuron membrane excitability by a tripeptide.

Autor:	Shelykh TN; Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg, 199034, Russia. shelt76@mail.ru., Rogachevsky IV; Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg, 199034, Russia., Nozdrachev AD; Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg, 199034, Russia., Veselkina OS; Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg, 199034, Russia., Podzorova SA; Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg, 199034, Russia., Krylov BV; Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg, 199034, Russia., Plakhova VB; Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg, 199034, Russia.
Jazyk:	angličtina
Zdroj:	Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2016; Vol. 466, pp. 77-80. Date of Electronic Publication: 2016 Mar 31.
DOI:	10.1134/S1607672916010191
Abstrakt:	Using the whole-cell patch-clamp method, the ability of arginine-containing tripeptide Ac-RER-NH2, dipeptide Ac-RR-NH2, and free Arg molecule to modulate the membrane excitability of nociceptors was studied. Extracellular Ac-RER-NH2 upon interaction with the outer membrane of the nociceptive neuron decreases the Zeff value of the activation gating system of Nav1.8 channels. Thus, the tripeptide Ac-RER-NH2 can be considered as a new effective and safe analgesic.
Databáze:	MEDLINE
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