Soft Tissue Regeneration under the Effect of Wound Coating Based on Chitosan (Natural Biopolymer).

Autor: Gladkova EV; Saratov Research Institute of Traumatology and Orthopedics, Ministry of Health of the Russian Federation, Saratov, Russia. gladckowa.katya@yandex.ru., Babushkina IV; Saratov Research Institute of Traumatology and Orthopedics, Ministry of Health of the Russian Federation, Saratov, Russia., Norkin IA; Saratov Research Institute of Traumatology and Orthopedics, Ministry of Health of the Russian Federation, Saratov, Russia., Mamonova IA; Saratov Research Institute of Traumatology and Orthopedics, Ministry of Health of the Russian Federation, Saratov, Russia., Puchin'yan DM; Saratov Research Institute of Traumatology and Orthopedics, Ministry of Health of the Russian Federation, Saratov, Russia., Konyuchenko EA; Saratov Research Institute of Traumatology and Orthopedics, Ministry of Health of the Russian Federation, Saratov, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2016 Mar; Vol. 160 (5), pp. 715-7. Date of Electronic Publication: 2016 Mar 29.
DOI: 10.1007/s10517-016-3258-9
Abstrakt: We developed wound coating based on natural biopolymer chitosan with additional components (ceruloplasmin, L-asparaginic acid, and glycerol). Experiments on albino male rats demonstrated its regeneratory, antioxidant, and antibacterial effects on wounds involving all layers of the skin. Due to chemical composition and buffer component, the biodegraded wound coating optimizes all phases of the wound process, accelerates by 22-28% the reparative regeneration, and leads to anatomic and functional restoration of injured sites. High absorption capacity recommends its use in the treatment of wounds with profuse exudation.
Databáze: MEDLINE
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