translin Is Required for Metabolic Regulation of Sleep.

Autor:	Murakami K; Department of Biology, University of Nevada, Reno, NV 89557.; Department of Biological Sciences, Florida Atlantic University, John D MacArthur Campus, Jupiter, FL, USA., Yurgel ME; Department of Biology, University of Nevada, Reno, NV 89557.; Department of Biological Sciences, Florida Atlantic University, John D MacArthur Campus, Jupiter, FL, USA., Stahl BA; Department of Biological Sciences, Florida Atlantic University, John D MacArthur Campus, Jupiter, FL, USA., Masek P; Department of Biology, SUNY Binghamton, Binghamton, NY 13902., Mehta A; Department of Biology, University of Nevada, Reno, NV 89557., Heidker R; Department of Biology, University of Nevada, Reno, NV 89557., Bollinger W; Department of Biology, University of Nevada, Reno, NV 89557.; Department of Biological Sciences, Florida Atlantic University, John D MacArthur Campus, Jupiter, FL, USA., Gingras RM; Department of Biology, Hofstra University, Hempstead, NY, 11549., Kim YJ; School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, South Korea., Ja WW; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL 33458., Suter B; University of Bern, Institute of Cell Biology, Bern, Switzerland, CH-3012., DiAngelo JR; Department of Biology, Hofstra University, Hempstead, NY, 11549.; Division of Science, Penn State Berks, Reading, PA 19610., Keene AC; Department of Biology, University of Nevada, Reno, NV 89557.; Department of Biological Sciences, Florida Atlantic University, John D MacArthur Campus, Jupiter, FL, USA.
Jazyk:	angličtina
Zdroj:	Current biology : CB [Curr Biol] 2016 Apr 04; Vol. 26 (7), pp. 972-980. Date of Electronic Publication: 2016 Mar 24.
DOI:	10.1016/j.cub.2016.02.013
Abstrakt:	Dysregulation of sleep or feeding has enormous health consequences. In humans, acute sleep loss is associated with increased appetite and insulin insensitivity, while chronically sleep-deprived individuals are more likely to develop obesity, metabolic syndrome, type II diabetes, and cardiovascular disease. Conversely, metabolic state potently modulates sleep and circadian behavior; yet, the molecular basis for sleep-metabolism interactions remains poorly understood. Here, we describe the identification of translin (trsn), a highly conserved RNA/DNA binding protein, as essential for starvation-induced sleep suppression. Strikingly, trsn does not appear to regulate energy stores, free glucose levels, or feeding behavior suggesting the sleep phenotype of trsn mutant flies is not a consequence of general metabolic dysfunction or blunted response to starvation. While broadly expressed in all neurons, trsn is transcriptionally upregulated in the heads of flies in response to starvation. Spatially restricted rescue or targeted knockdown localizes trsn function to neurons that produce the tachykinin family neuropeptide Leucokinin. Manipulation of neural activity in Leucokinin neurons revealed these neurons to be required for starvation-induced sleep suppression. Taken together, these findings establish trsn as an essential integrator of sleep and metabolic state, with implications for understanding the neural mechanism underlying sleep disruption in response to environmental perturbation. (Copyright © 2016 Elsevier Ltd. All rights reserved.)
Databáze:	MEDLINE
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