Tumour infiltrating lymphocytes correlate with improved survival in patients with oesophageal adenocarcinoma.

Autor:	Noble F; Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Somers Cancer Research Building (MP824), Southampton General Hospital, Tremona Road, Southampton, UK. f.noble@soton.ac.uk.; Department of Surgery, University Hospital Southampton NHS Foundation Trust, Southampton, UK. f.noble@soton.ac.uk., Mellows T; Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Somers Cancer Research Building (MP824), Southampton General Hospital, Tremona Road, Southampton, UK., McCormick Matthews LH; Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Somers Cancer Research Building (MP824), Southampton General Hospital, Tremona Road, Southampton, UK., Bateman AC; Department of Cellular Pathology, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Harris S; Public Health Sciences and Medical Statistics, Faculty of Medicine, University of Southampton, Southampton, UK., Underwood TJ; Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Somers Cancer Research Building (MP824), Southampton General Hospital, Tremona Road, Southampton, UK.; Department of Surgery, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Byrne JP; Department of Surgery, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Bailey IS; Department of Surgery, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Sharland DM; Department of Surgery, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Kelly JJ; Department of Surgery, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Primrose JN; Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Somers Cancer Research Building (MP824), Southampton General Hospital, Tremona Road, Southampton, UK.; Department of Surgery, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Sahota SS; Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Somers Cancer Research Building (MP824), Southampton General Hospital, Tremona Road, Southampton, UK., Bateman AR; Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Somers Cancer Research Building (MP824), Southampton General Hospital, Tremona Road, Southampton, UK.; Cancer Care, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Thomas GJ; Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Somers Cancer Research Building (MP824), Southampton General Hospital, Tremona Road, Southampton, UK.; Department of Cellular Pathology, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Ottensmeier CH; Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Somers Cancer Research Building (MP824), Southampton General Hospital, Tremona Road, Southampton, UK.; Cancer Care, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Jazyk:	angličtina
Zdroj:	Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2016 Jun; Vol. 65 (6), pp. 651-62. Date of Electronic Publication: 2016 Mar 28.
DOI:	10.1007/s00262-016-1826-5
Abstrakt:	Background: Oesophageal adenocarcinoma (OAC) is increasingly common in the west, and survival remains poor at 10-15 % at 5 years. Immune responses are increasingly implicated as a determining factor of tumour progression. The ability of lymphocytes to recognise tumour antigens provides a mechanism for a host immune attack against cancer providing a potential treatment strategy. Materials and Methods: Tumour infiltrating lymphocytes (TILs: CD3+, CD4+, CD8+ and FOXp3+) were assessed by immunohistochemistry using tissue microarrays in a contemporary and homogeneous cohort of OAC patients (n = 128) undergoing curative treatment. Results: Multivariate analysis identified three independent prognostic factors for improved cancer-specific survival (CSS): increased CD8+ TILs (p = 0.003), completeness of resection (p < 0.0001) and lower pathological N stage (p < 0.0001). Independent prognostic factors for favourable disease-free survival included surgery-only treatment (p = 0.015), completeness of resection (p = 0.001), increased CD8+ TILs (p < 0.0001) and reduced pathological N stage (p < 0.0001). Higher levels of TILs in the pathological specimen were associated with significant pathological response to neoadjuvant chemotherapy (NAC). On multivariate analysis increased levels of CD4+ (p = 0.017) and CD8+ TILs (p = 0.005) were associated with significant local tumour regression and lymph node downstaging, respectively. Discussion: Our results establish an association of TILs and survival in OAC, as seen in other solid tumours, and identify particular TIL subsets that are present at higher levels in patients who responded to NAC compared to non-responders. These findings highlight potential therapeutic strategies in EAC based on utilising the host immunological response and highlight the immune responses biomarker potential.
Databáze:	MEDLINE
Externí odkaz:	Full text from SpringerLink