Different components of conditioned food aversion memory.

Autor: Nikitin VP; P.K. Anokhin Institute of Normal Physiology, Laboratory of Neurochemistry, Mokhovaya 11/4, 125009 Moscow, Russian Federation. Electronic address: vpnikitin48@gmail.com., Solntseva SV; P.K. Anokhin Institute of Normal Physiology, Laboratory of Neurochemistry, Mokhovaya 11/4, 125009 Moscow, Russian Federation. Electronic address: sols3@yandex.ru., Kozyrev SA; P.K. Anokhin Institute of Normal Physiology, Laboratory of Neurochemistry, Mokhovaya 11/4, 125009 Moscow, Russian Federation., Nikitin PV; P.K. Anokhin Institute of Normal Physiology, Laboratory of Neurochemistry, Mokhovaya 11/4, 125009 Moscow, Russian Federation., Shevelkin AV; P.K. Anokhin Institute of Normal Physiology, Laboratory of Neurochemistry, Mokhovaya 11/4, 125009 Moscow, Russian Federation; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 North Wolfe Street, CMSC 9-115, Baltimore, MD 21287, United States. Electronic address: shevelkin@gmail.com.
Jazyk: angličtina
Zdroj: Brain research [Brain Res] 2016 Jul 01; Vol. 1642, pp. 104-113. Date of Electronic Publication: 2016 Mar 23.
DOI: 10.1016/j.brainres.2016.03.017
Abstrakt: Memory reconsolidation processes and protein kinase Mzeta (PKMzeta) activity in memory maintenance and reorganization are poorly understood. Therefore, we examined memory reconsolidation and PKMzeta activity during the maintenance and reorganization of a conditioned food aversion memory among snails. These processes were specifically evaluated after administration of a serotonin receptor antagonist (methiothepin), NMDA glutamate receptor antagonist (MK-801), protein synthesis inhibitor (cycloheximide; CYH), or PKMzeta inhibitor (zeta inhibitory peptide; ZIP) either 2 or 10 days after aversion training. Two days post-training, injections of MK-801 or CYH, combined with a conditioned stimulus reminder, caused amnesia development, and a second training 11 days after this induction did not lead to long-term memory formation. Interestingly, MK-801 or CYH injections and the reminder 10 days after training did not affect memory retrieval. Methiothepin and the reminder, or ZIP without the reminder, at 2 and 10 days after training led to memory impairment, while a second training 11 days after amnesia induction resulted in memory formation. These results suggest that the maintenance of a conditioned food aversion involves two different components with variable dynamics. One component could be characterized by memory strengthening over time and involve N-methyl-D-aspartate receptors and protein synthesis reconsolidation at early, but not late, training stages. The other memory component could involve serotonin-dependent reconsolidation and Mzeta-like kinase activity at both early and late stages after learning. Deficiencies within these two components led to various forms of memory impairment, which differed in terms of the formation of a conditioned food aversion during the second training.
(Copyright © 2016 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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