Early intake of long-chain polyunsaturated fatty acids preserves brain structure and function in diet-induced obesity.

Autor: Arnoldussen IA; Department of Anatomy, Radboud university medical center, 6595 EZ, Nijmegen, the Netherlands; Donders Institute for Brain, Cognition, and Behaviour, 6525 EN, Nijmegen, the Netherlands., Zerbi V; Department of Anatomy, Radboud university medical center, 6595 EZ, Nijmegen, the Netherlands; Donders Institute for Brain, Cognition, and Behaviour, 6525 EN, Nijmegen, the Netherlands., Wiesmann M; Department of Anatomy, Radboud university medical center, 6595 EZ, Nijmegen, the Netherlands; Donders Institute for Brain, Cognition, and Behaviour, 6525 EN, Nijmegen, the Netherlands; Department of Geriatric Medicine, Radboud university medical center, 6595 CG, Nijmegen, the Netherlands., Noordman RH; Department of Anatomy, Radboud university medical center, 6595 EZ, Nijmegen, the Netherlands; Donders Institute for Brain, Cognition, and Behaviour, 6525 EN, Nijmegen, the Netherlands., Bolijn S; Department of Anatomy, Radboud university medical center, 6595 EZ, Nijmegen, the Netherlands; Donders Institute for Brain, Cognition, and Behaviour, 6525 EN, Nijmegen, the Netherlands., Mutsaers MP; Department of Anatomy, Radboud university medical center, 6595 EZ, Nijmegen, the Netherlands; Donders Institute for Brain, Cognition, and Behaviour, 6525 EN, Nijmegen, the Netherlands., Dederen PJ; Department of Anatomy, Radboud university medical center, 6595 EZ, Nijmegen, the Netherlands; Donders Institute for Brain, Cognition, and Behaviour, 6525 EN, Nijmegen, the Netherlands., Kleemann R; TNO Metabolic Health Research, 2333 CK, Leiden, the Netherlands., Kooistra T; TNO Metabolic Health Research, 2333 CK, Leiden, the Netherlands., van Tol EA; Mead Johnson Pediatric Nutrition Institute, 6545 CJ, Nijmegen, the Netherlands., Gross G; Mead Johnson Pediatric Nutrition Institute, 6545 CJ, Nijmegen, the Netherlands., Schoemaker MH; Mead Johnson Pediatric Nutrition Institute, 6545 CJ, Nijmegen, the Netherlands., Heerschap A; Mead Johnson Pediatric Nutrition Institute, 6545 CJ, Nijmegen, the Netherlands; Department of Radiology and Nuclear Medicins, Radboud university medical center, 6595 GA Nijmegen, the Netherlands., Wielinga PY; TNO Metabolic Health Research, 2333 CK, Leiden, the Netherlands., Kiliaan AJ; Department of Anatomy, Radboud university medical center, 6595 EZ, Nijmegen, the Netherlands; Donders Institute for Brain, Cognition, and Behaviour, 6525 EN, Nijmegen, the Netherlands. Electronic address: Amanda.Kiliaan@Radboudumc.nl.
Jazyk: angličtina
Zdroj: The Journal of nutritional biochemistry [J Nutr Biochem] 2016 Apr; Vol. 30, pp. 177-88. Date of Electronic Publication: 2016 Jan 21.
DOI: 10.1016/j.jnutbio.2015.12.011
Abstrakt: Worldwide, the incidence of obesity is increasing at an alarming rate, and the number of children with obesity is especially worrisome. These developments raise concerns about the physical, psychosocial and cognitive consequences of obesity. It was shown that early dietary intake of arachidonic acid (ARA) and docosahexaenoic acid (DHA) can reduce the detrimental effects of later obesogenic feeding on lipid metabolism and adipogenesis in an animal model of mild obesity. In the present study, the effects of early dietary ARA and DHA on cognition and brain structure were examined in mildly obesogenic ApoE*3Leiden mouse model. We used cognitive tests and neuroimaging during early and later life. During their early development after weaning (4-13weeks of age), mice were fed a chow diet or ARA and DHA diet for 8 weeks and then switched to a high-fat and high-carbohydrate (HFHC) diet for 12weeks (14-26weeks of age). An HFHC-diet led to increased energy storage in white adipose tissue, increased cholesterol levels, decreased triglycerides levels, increased cerebral blood flow and decreased functional connectivity between brain regions as well as cerebrovascular and gray matter integrity. ARA and DHA intake reduced the HFHC-diet-induced increase in body weight, attenuated plasma triglycerides levels and improved cerebrovasculature, gray matter integrity and functional connectivity in later life. In conclusion, an HFHC diet causes adverse structural brain and metabolic adaptations, most of which can be averted by dietary ARA and DHA intake early in life supporting metabolic flexibility and cerebral integrity later in life.
(Copyright © 2016 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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