Asian consensus on the relationship between obesity and gastrointestinal and liver diseases.

Autor: Koh JC; Department of Medicine, National University of Singapore, Singapore., Loo WM; Department of Medicine, National University of Singapore, Singapore., Goh KL; Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Sugano K; Jichi Medical School, Tochigi, Japan., Chan WK; Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Chiu WY; Department of Surgery, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong., Choi MG; Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Korea., Gonlachanvit S; Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Lee WJ; Department of Surgery, Min-Sheng General Hospital, Taoyuan, Taiwan., Lee WJ; Department of Medicine, National University of Singapore, Singapore., Lee YY; School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia., Lesmana LA; Department of Internal Medicine, Faculty of Medicine, University of Indonesia - Cipto Mangunkusumo Hospital, Jakarta Pusat, Indonesia., Li YM; The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China., Liu CJ; Department of Internal Medicine, Graduate Institute of Clinical Medicine, Hepatitis Research Center, National Taiwan University College of Medicine and National Taiwan University Hospital, Taiwan., Matsuura B; Department of Lifestyle-Related Medicine and Endocrinology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan., Nakajima A; Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, Japan., Ng EK; Department of Surgery, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong., Sollano JD; Department of Medicine, University of Santo Tomas, Manila, Philippines., Wong SK; Department of Surgery, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong., Wong VW; Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong., Yang Y; Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China., Ho KY; Department of Medicine, National University of Singapore, Singapore., Dan YY; Department of Medicine, National University of Singapore, Singapore.
Jazyk: angličtina
Zdroj: Journal of gastroenterology and hepatology [J Gastroenterol Hepatol] 2016 Aug; Vol. 31 (8), pp. 1405-13.
DOI: 10.1111/jgh.13385
Abstrakt: The incidence of obesity is increasing in Asia, with implications on gastrointestinal (GI) and liver diseases. The Gut and Obesity in Asia Workgroup comprises regional experts with the aim of studying relationship between obesity and the GI and liver diseases in Asia. Through literature review and the modified Delphi process, consensus statements examining the impact of obesity on esophageal, gastric, pancreatic, colorectal, and liver diseases, exploring relationship between gut microbiome and obesity, and assessing obesity therapies have been produced by the Gut and Obesity in Asia Workgroup. Sixteen experts participated with 9/15 statements having strong consensus (>80% agreement). The prevalence of obesity in Asia is increasing (100% percentage agreement in brackets), and this increased prevalence of obesity will result in a greater burden of obesity-related GI and liver diseases (93.8%). There was consensus that obesity increases the risk of gastric cancer (75%) and colorectal neoplasia (87.5%). Obesity was also associated with Barrett's esophagus and esophageal adenocarcinoma (66.7%) and pancreatic cancer (66.7%) in Asia. The prevalence of non-alcoholic fatty liver disease (NAFLD) in Asia is on the rise (100%), and the risk of NAFLD in Asia (100%) is increased by obesity. Obesity is a risk factor for the development of hepatocellular carcinoma (93.8%). Regarding therapy, it was agreed that bariatric surgery was an effective treatment modality for obesity (93.8%) but there was less agreement on its benefit for NAFLD (62.5%). These experts' consensus on obesity and GI diseases in Asia forms the basis for further research, and its translation into addressing this emerging issue.
(© 2016 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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