Angiotensinogen (AGT) M235T, AGT T174M and Angiotensin-1-Converting Enzyme (ACE) I/D Gene Polymorphisms in Essential Hypertension: Effects on Ramipril Efficacy.

Autor:	Kolovou V; Cardiology Department, Molecular Immunology Laboratory, Onassis Cardiac Surgery Center Athens, Greece; Molecular Immunology Laboratory, Onassis Cardiac Surgery Center Athens, Greece., Lagou E; Molecular Immunology Laboratory, Onassis Cardiac Surgery Center Athens, Greece., Mihas C; Internal Medicine Department, General Hospital of Kimi, Evia Island, Greece., Vasiliki G; Cardiology Department, Thriassio Hospital, Magoula, Greece., Katsiki N; Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippocration Hospital, Thessaloniki, Greece., Kollia A; Orthopedic and Urologic Departments, Veterans Administration Hospital (NIMTS), Athens, Greece., Triposkiadis F; Department of Cardiology, Larissa University Hospital, Larissa, Greece., Degiannis D; Molecular Immunology Laboratory, Onassis Cardiac Surgery Center Athens, Greece., Mavrogeni S; Cardiology Department, Molecular Immunology Laboratory, Onassis Cardiac Surgery Center Athens, Greece., Kolovou G; Cardiology Department, Molecular Immunology Laboratory, Onassis Cardiac Surgery Center Athens, Greece.
Jazyk:	angličtina
Zdroj:	The open cardiovascular medicine journal [Open Cardiovasc Med J] 2015 Dec 29; Vol. 9, pp. 118-26. Date of Electronic Publication: 2015 Dec 29 (Print Publication: 2015).
DOI:	10.2174/1874192401509010118
Abstrakt:	Background: Hypertension, one of the most important risk factors for premature cardiovascular disease, is a major worldwide public health problem. Angiotensin-1-converting enzyme (ACE) and angiotensinogen (AGT) gene polymorphisms are thought to be associated with primary hypertension. In the present study, we examined the frequency of these gene polymorphisms in an adult population with and without essential hypertension. Furthermore, we evaluated the effect of ACE and AGT gene polymorphisms on ramipril treatment efficacy in the hypertensive patients. Methods: A total of 166 adults (83 hypertensives and 83 normotensives) were involved in the study and genotyped for AGTM235T (rs699), AGTT174M (rs4762) and ACEI/D (rs1799752) gene polymorphisms. Results: The genotype and allele distribution of the AGTM235T variant significantly differed between hypertensives and normotensives [odds ratio (OR) = 1.57% (T vs M allele), 95% confidence intervals (CIs): 1.01 - 2.44; p=0.045 for hypertensives]. However, none of the 3 studied Simple Nucleotide Polymorphisms were associated with the blood pressure-lowering response to ramipril. Conclusion: These results suggest that AGTM235T gene polymorphism is associated with essential hypertension. However, none of the AGTM235T, AGTT174M and ACEI/D gene polymorphisms influenced ramipril effectiveness.
Databáze:	MEDLINE
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