Chronic Recurrent Vogt-Koyanagi-Harada Disease and Development of 'Sunset Glow Fundus' Predict Worse Retinal Sensitivity.

Autor: Abu El-Asrar AM; a Department of Ophthalmology , College of Medicine, King Saud University , Riyadh , Saudi Arabia.; b Dr Nasser Al-Rashid Research Chair in Ophthalmology., Al Mudhaiyan T; a Department of Ophthalmology , College of Medicine, King Saud University , Riyadh , Saudi Arabia., Al Najashi AA; a Department of Ophthalmology , College of Medicine, King Saud University , Riyadh , Saudi Arabia., Hemachandran S; a Department of Ophthalmology , College of Medicine, King Saud University , Riyadh , Saudi Arabia., Hariz R; a Department of Ophthalmology , College of Medicine, King Saud University , Riyadh , Saudi Arabia., Mousa A; a Department of Ophthalmology , College of Medicine, King Saud University , Riyadh , Saudi Arabia., Al-Muammar A; a Department of Ophthalmology , College of Medicine, King Saud University , Riyadh , Saudi Arabia.
Jazyk: angličtina
Zdroj: Ocular immunology and inflammation [Ocul Immunol Inflamm] 2017 Aug; Vol. 25 (4), pp. 475-485. Date of Electronic Publication: 2016 Mar 22.
DOI: 10.3109/09273948.2016.1139730
Abstrakt: Purpose: To investigate prognostic factors for retinal sensitivity assessed by microperimetry in patients with Vogt-Koyanagi-Harada (VKH) disease.
Methods: In total, 34 patients with initial-onset acute disease and 19 patients with chronic recurrent disease were retrospectively evaluated.
Results: The mean follow-up period was 40.4 ± 40.5 months. Sensitivity was significantly worse in eyes with more severe anterior segment inflammation at presentation, as indicated by the presence of mutton-fat keratic precipitates, anterior chamber reaction ≥2+, and posterior synechiae. Chronic recurrent presentation, development of complications, and 'sunset glow fundus' were significantly associated with worse sensitivity. Using logistic regression analysis, better sensitivity was significantly associated with initial-onset acute presentation (odds ratio, OR = 6.9; 95% confidence interval, CI = 1.53-9.66).
Conclusions: Chronic recurrent presentation and development of complications and 'sunset glow fundus' are associated with a worse sensitivity outcome.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje