The TGF-β Signalling Network in Muscle Development, Adaptation and Disease.

Autor: Chen JL; Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.; Department of Molecular and Translational Sciences, Monash University, Melbourne, VIC, Australia.; Muscle Research and Therapeutics Development, Baker IDI Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia., Colgan TD; Muscle Research and Therapeutics Development, Baker IDI Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia.; Department of Physiology, The University of Melbourne, Melbourne, VIC, Australia., Walton KL; Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia.; Department of Molecular and Translational Sciences, Monash University, Melbourne, VIC, Australia., Gregorevic P; Muscle Research and Therapeutics Development, Baker IDI Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia. Paul.Gregorevic@bakeridi.edu.au.; Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia. Paul.Gregorevic@bakeridi.edu.au.; Department of Physiology, The University of Melbourne, Melbourne, VIC, Australia. Paul.Gregorevic@bakeridi.edu.au.; Department of Neurology, School of Medicine, The University of Washington, Seattle, WA, USA. Paul.Gregorevic@bakeridi.edu.au., Harrison CA; Centre for Endocrinology and Metabolism, Hudson Institute of Medical Research, Clayton, VIC, 3168, Australia. Craig.Harrison@hudson.org.au.; Department of Molecular and Translational Sciences, Monash University, Melbourne, VIC, Australia. Craig.Harrison@hudson.org.au.; Department of Physiology, Monash University, Melbourne, VIC, Australia. Craig.Harrison@hudson.org.au.
Jazyk: angličtina
Zdroj: Advances in experimental medicine and biology [Adv Exp Med Biol] 2016; Vol. 900, pp. 97-131.
DOI: 10.1007/978-3-319-27511-6_5
Abstrakt: Skeletal muscle possesses remarkable ability to change its size and force-producing capacity in response to physiological stimuli. Impairment of the cellular processes that govern these attributes also affects muscle mass and function in pathological conditions. Myostatin, a member of the TGF-β family, has been identified as a key regulator of muscle development, and adaptation in adulthood. In muscle, myostatin binds to its type I (ALK4/5) and type II (ActRIIA/B) receptors to initiate Smad2/3 signalling and the regulation of target genes that co-ordinate the balance between protein synthesis and degradation. Interestingly, evidence is emerging that other TGF-β proteins act in concert with myostatin to regulate the growth and remodelling of skeletal muscle. Consequently, dysregulation of TGF-β proteins and their associated signalling components is increasingly being implicated in muscle wasting associated with chronic illness, ageing, and inactivity. The growing understanding of TGF-β biology in muscle, and its potential to advance the development of therapeutics for muscle-related conditions is reviewed here.
Databáze: MEDLINE
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