The clinical relevance and prognostic significance of microsomal epoxide hydrolase gene polymorphisms and their susceptibility to acquired aplastic anemia: an Egyptian study.

Autor: Makhlouf MM; a Department of Clinical and Chemical Pathology , Faculty of Medicine, Cairo University , Cairo , Egypt and., Magdy RI; b Department of Pediatric , Faculty of Medicine, Cairo University , Cairo , Egypt.
Jazyk: angličtina
Zdroj: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals [Biomarkers] 2016 Jul; Vol. 21 (5), pp. 416-23. Date of Electronic Publication: 2016 Mar 21.
DOI: 10.3109/1354750X.2016.1141992
Abstrakt: Background: Microsomal epoxide hydrolase enzyme (mEPHX) is involved in xenobiotics detoxification. Two variants of mEPHX, Tyr113His and His139Arg, have been described. Both may lead to acquired aplastic anemia (AA).
Objectives: Assessing mEPHX genetic polymorphisms and detecting their impact on susceptibility and prognosis in Egyptian AA patients.
Participants and Methods: mEPHX 113 and 139 genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 100 patients with AA and 100 control subjects.
Results: Both mEPHX Tyr113His and His139Arg gene polymorphisms were associated with increased risk of developing AA, and have a significant impact of bad prognosis (p value < 0.01).
Conclusions: These mEPHX gene polymorphisms can be considered as risk factors and predictive molecular markers for prognosis in AA patients.
Databáze: MEDLINE
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