| Abstrakt: |
In this study, for the first time the expression of β₂ and β₄ isoforms of RARβ gene was investigated in group of 19 patients with the newly diagnosed multiple myeloma. The expression of both RARβ₂ and RARβ₄ isoforms was detected in all patients, but it was different and had opposite tendency. We showed that RARβ₄ expression level positively correlated with VEGF-A and VEGFR1 expression levels. It was found that higher levels of RARβ₄/VEGF-A/VEGFR1 co-expression were defined of patients with statistically significant increase of plasma cell level and paraprotein concentration. The median overall survival was lower in patients with RARβ₄, over-expression, while the maximal median overall survival was observed of patients with RARβ₂ down-regulation and nearly absolute RARβ₄inactivation. |
