Evaluation of a Portable Haemoglobin Metre Performance in Children with Sickle Cell Disease and Implications for Healthcare in Resource-poor Settings.

Autor:	Olatunya OS; Department of Paediatrics, Ekiti State University, Ado Ekiti, 360101 Nigeria ladeletunya@yahoo.com., Olu-Taiwo A; Department of Haematology and Blood Transfusion, Ekiti State University, Ado Ekiti, 360101 Nigeria., Ogundare EO; Department of Paediatrics, Ekiti State University, Ado Ekiti, 360101 Nigeria., Oluwayemi IO; Department of Paediatrics, Ekiti State University, Ado Ekiti, 360101 Nigeria., Olaleye AO; Department of Community Medicine, Obafemi Awolowo University Teaching Hospital, Ile -Ife, 220105 Nigeria., Fadare JO; Department of Clinical Pharmacology, Ekiti State University, Ado Ekiti, 360101 Nigeria., Adekoya-Benson T; Department of Haematology and Blood Transfusion, Ekiti State University Teaching Hospital, Ado Ekiti, 360101 Nigeria., Fatunla O; Department of Paediatrics, Ekiti State University, Ado Ekiti, 360101 Nigeria., Agaja OT; Department of Paediatrics, Ekiti State University, Ado Ekiti, 360101 Nigeria., Omoniyi E; Department of Paediatrics, Ekiti State University, Ado Ekiti, 360101 Nigeria., Oluwadiya KS; Department of Surgery, Ekiti State University, Ado Ekiti, 360101 Nigeria.
Jazyk:	angličtina
Zdroj:	Journal of tropical pediatrics [J Trop Pediatr] 2016 Aug; Vol. 62 (4), pp. 316-23. Date of Electronic Publication: 2016 Mar 19.
DOI:	10.1093/tropej/fmw015
Abstrakt:	Background: Sub-Saharan Africa has the largest burden and worst outcome of sickle cell disease (SCD). This gloomy outlook has been attributed to the lack of use of simple and cost-effective measures for diagnosis and treatment of the disease. Although haematology analysers are the gold standard for accurate measurement of haemoglobin (Hb) concentration, they are often out of reach of most health facilities in resource-poor settings, thus creating a care gap. We conducted this study to examine the agreement between a point-of-care device and haematology analyser for determining the Hb concentration in children with SCD and its usefulness in resource-poor settings. Methods: Ethylenediaminetetraacetic acid blood samples collected from participants were processed to estimate their Hb concentration using two devices (Sysmex KX21N haematology analyser and portable mission Hb device). The agreement between the two sets of measurements was assessed by the Bland and Altman method. Results: The intraclass and concordance correlation coefficients were 0.854 and 0.936, respectively. Sensitivity and specificity were 84.2% and 98.6%, respectively. The positive and negative predictive values were 94.1% and 96.0%, respectively. The Bland and Altman's limit of agreement was -2.3 to 1.6 and the mean difference was -0.34 with non-significant variability between the two measurements (p  =  0.949). Conclusion: Hb concentration determined by the portable testing system is comparable with that determined by the haematology analyser. We recommend its use as a point-of-care device for determining Hb concentration of SCD children in resource-poor settings where haematology analysers are not available. (© The Author [2016]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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