Methotrexate-induced necrolysis in tumoral-stage mycosis fungoides: a challenging diagnosis.

Autor: Mna AB; La Rabta Hospital., Souissi A, Halouani S, El Euch D, Zahani A, Kchir N, Zaraa I, Mokni M
Jazyk: angličtina
Zdroj: Dermatology online journal [Dermatol Online J] 2016 Jan 15; Vol. 22 (1). Date of Electronic Publication: 2016 Jan 15.
Abstrakt: Methotrexate-induced cutaneous ulceration is a rare but potentially serious drug adverse reaction. This adverse reaction of methotrexate therapy has been initially described in psoriasis patients and is unusual in patients with cutaneous T-cell lymphoma. In 1978, Mc Donald et al reported the first three cases of cutaneous ulcerations in patients treated for a mycosis fungoides with intravenous infusions of methotrexate. Since then, few cases of methotrexate-induced skin ulcers in patients with mycosis fungoides have been published. We report an additional patient with erythrodermic mycosis fungoides who developed cutaneous ulcerations as a sole manifestation of methotrexate toxicity.
Databáze: MEDLINE