Restrictive pattern on spirometry: association with cardiovascular risk and level of physical activity in asymptomatic adults.

Autor:	Sperandio EF; Departamento de Ciências do Movimento Humano, Universidade Federal de São Paulo, Santos, SP, Brasil., Arantes RL; AngioCorpore - Instituto de Medicina Cardiovascular, Santos, SP, Brasil., Matheus AC; Departamento de Ciências do Movimento Humano, Universidade Federal de São Paulo, Santos, SP, Brasil., Silva RP; Departamento de Ciências do Movimento Humano, Universidade Federal de São Paulo, Santos, SP, Brasil., Lauria VT; Departamento de Ciências do Movimento Humano, Universidade Federal de São Paulo, Santos, SP, Brasil., Romiti M; AngioCorpore - Instituto de Medicina Cardiovascular, Santos, SP, Brasil., Gagliardi AR; AngioCorpore - Instituto de Medicina Cardiovascular, Santos, SP, Brasil., Dourado VZ; AngioCorpore - Instituto de Medicina Cardiovascular, Santos, SP, Brasil.
Jazyk:	English; Portuguese
Zdroj:	Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia [J Bras Pneumol] 2016 Jan-Feb; Vol. 42 (1), pp. 22-8.
DOI:	10.1590/S1806-37562016000000030
Abstrakt:	Objective: To determine whether a restrictive pattern on spirometry is associated with the level of physical activity in daily life (PADL), as well as with cardiovascular disease (CVD) risk factors, in asymptomatic adults. Methods: A total of 374 participants (mean age, 41 ± 14 years) underwent spirometry, which included the determination of FVC and FEV1. A restrictive pattern on spirometry was defined as an FEV1/FVC ratio > 0.7 and an FVC < 80% of the predicted value. After conducting demographic, anthropometric, and CVD risk assessments, we evaluated body composition, muscle function, and postural balance, as well as performing cardiopulmonary exercise testing and administering the six-minute walk test. The PADL was quantified with a triaxial accelerometer. Results: A restrictive pattern on spirometry was found in 10% of the subjects. After multivariate logistic regression, adjusted for confounders (PADL and cardiorespiratory fitness), the following variables retained significance (OR; 95% CI) as predictors of a restrictive pattern: systemic arterial hypertension (17.5; 1.65-184.8), smoking (11.6; 1.56-87.5), physical inactivity (8.1; 1.43-46.4), larger center-of-pressure area while standing on a force platform (1.34; 1.05-1.71); and dyslipidemia (1.89; 1.12-1.98). Conclusions: A restrictive pattern on spirometry appears to be common in asymptomatic adults. We found that CVD risk factors, especially systemic arterial hypertension, smoking, and physical inactivity, were directly associated with a restrictive pattern, even when the analysis was adjusted for PADL and cardiorespiratory fitness. Longitudinal studies are needed in order to improve understanding of the etiology of a restrictive pattern as well as to aid in the design of preventive strategies.
Databáze:	MEDLINE
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