Topical diltiazem for pain after closed hemorrhoidectomy.

Autor:	Rodríguez-Wong U; Maestría en Ciencias de la Salud, Instituto Politécnico Nacional, Ciudad de México, México; Servicio de Cirugía, Hospital Juárez de México, Ciudad de México, México. Electronic address: ulisesromed@prodigy.net.mx., Ocharán-Hernández ME; Área de Investigación Clínica de la Maestría en Ciencias de la Salud, Escuela Superior de Medicina, Sección de Posgrado e Investigación, Instituto Politécnico Nacional, Ciudad de México, México., Toscano-Garibay J; Dirección de Investigación, Hospital Juárez de México, Ciudad de México, México.
Jazyk:	English; Spanish; Castilian
Zdroj:	Revista de gastroenterologia de Mexico [Rev Gastroenterol Mex] 2016 Apr-Jun; Vol. 81 (2), pp. 74-9. Date of Electronic Publication: 2016 Mar 12.
DOI:	10.1016/j.rgmx.2016.02.001
Abstrakt:	Background: Anal sphincter spasm contributes to the appearance of postoperative pain following hemorrhoidectomy. Aim: To determine the efficacy of topical diltiazem in the control of post-hemorrhoidectomy pain. Material and Methods: A randomized, prospective, experimental, double-blind study was conducted on 2 groups of patients in the postoperative period of closed hemorrhoidectomy. Each group consisted of 17 patients. Group A received topical diltiazem in the anal region 3 times a day and group B received a placebo. Ketorolac was administered to both groups as rescue therapy. Results: In group A, the mean score on the visual analog scale was 2.97±1.18cm at 24h, 1.51±1.18cm at 48h, and 0.84±0.92cm at 72h. In group B, it was 6.82±1.9cm at 24h, 5.3±1.66cm at 48h, and 4.32±2.13cm at 72h (P<.001, 95% CI). The mean number of analgesic doses in group A was 2.41±0.87 at 24h, 1.11±0.85 at 48h, and 0.94±0.96 at 72h. In group B, it was 3.82±0.52 at 24h, 3.64±0.70 at 48h, and 2.88±1.26 at 72h (P<.001, 95% CI). Conclusions: In this study, topical administration of diltiazem resulted in a statistically significant reduction of postoperative pain in patients that underwent closed hemorrhoidectomy. (Copyright © 2016 Asociación Mexicana de Gastroenterología. Published by Masson Doyma México S.A. All rights reserved.)
Databáze:	MEDLINE
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