"The impact of debulking surgery in patients with node-positive epithelial ovarian cancer: Analysis of prognostic factors related to overall survival and progression-free survival after an extended long-term follow-up period".

Autor: Pereira A; Division of Gynecologic Oncology, Gregorio Marañón University General Hospital, C/Maiquez, 7, 28009 Madrid, Spain. Electronic address: apereiras@sego.es., Pérez-Medina T; Department of Gynecologic Surgery, Puerta de Hierro University Hospital, C/Joaquin Rodrigo, 2, 28222 Madrid, Spain., Magrina JF; Division of Gynecologic Surgery, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, 85259 AZ, USA., Magtibay PM; Division of Gynecologic Surgery, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, 85259 AZ, USA., Rodríguez-Tapia A; Department of Gynecology and Obstetrics, College of Medicine, Autonomous University, C/Arzobispo Morcillo, 4, 28029 Madrid, Spain., Cuesta-Guardiola T; Division of Gynecologic Oncology, Gregorio Marañón University General Hospital, C/Maiquez, 7, 28009 Madrid, Spain., Peregrin I; Department of Obstetrics and Gynecology, Bronx-Lebanon Hospital Center, 1650 Grand Concourse, Bronx, 10457 NY, USA., Mendizabal E; Division of Gynecologic Oncology, Gregorio Marañón University General Hospital, C/Maiquez, 7, 28009 Madrid, Spain., Lizarraga S; Division of Gynecologic Oncology, Gregorio Marañón University General Hospital, C/Maiquez, 7, 28009 Madrid, Spain., Ortiz-Quintana L; Division of Gynecologic Oncology, Gregorio Marañón University General Hospital, C/Maiquez, 7, 28009 Madrid, Spain.
Jazyk: angličtina
Zdroj: Surgical oncology [Surg Oncol] 2016 Mar; Vol. 25 (1), pp. 49-59. Date of Electronic Publication: 2016 Feb 10.
DOI: 10.1016/j.suronc.2015.12.005
Abstrakt: Objective: to estimate the prognostic factors associated with survival and progression free survival (PFS) in patients with node-positive epithelial ovarian cancer (EOC) after an extended long-term follow-up period.
Methods: Data was provided by the Tumor Registry of the Mayo Clinic, Scottsdale, Arizona on 116 node-positive EOC patients who underwent primary cytoreductive surgery observed over the period 1996-2014.
Results: At censoring date, 21 patients were alive (18%), 95 dead (82%), 18 without evidence of disease (NED) (15 alive, 3 dead) and 76 with evidence of disease (ED) (2 alive, 74 dead). Twenty-nine ED patients (38.2%) experienced a recurrence within 2 years, 53 patients (69.7%) before 5 years. No recurrences were recorded after 10 years. The median follow-up in alive patients was 169.8 months (1.20-207.9 months), 34.9 months (0.30-196.2 months) in dead patients, 128.4 months for NED patients (72.8-202.5 months) and 34.6 months (0.1-106.9 months) in ED patients. Multivariate analysis showed an increased risk of dead in patients with age ≥ 60 years (HR: 3.20; p < 0.002), stage IVA/B (compared with stage IIIA1/2, HR: 4.31; p < 0.001 and stage IIIB/C, HR: 5.31; p < 0.010) and incomplete surgery (compared with complete surgery, HR: 3.10; 95% CI, 1.41-6.77; p < 0.003) and a decreased PFS in stage IVA/B (compared with stages IIIB/C; p = 0.003 and stage IIIA; p = 0.000) and residual volume after surgery >0.6 cm (compared with residual disease <0.5 cm; p < 0.023).
Conclusions: prognostic factors for an extended long-term PFS are similar as those for survival, because after 17-year follow-up period, the majority of alive patients are NED patients.
(Copyright © 2016 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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