The Role of Topical Vitamin E in Scar Management: A Systematic Review.

Autor:	Tanaydin V; From the Department of Plastic Surgery, Maastricht University Medical Center, Maastricht, The Netherlands., Conings J; From the Department of Plastic Surgery, Maastricht University Medical Center, Maastricht, The Netherlands., Malyar M; From the Department of Plastic Surgery, Maastricht University Medical Center, Maastricht, The Netherlands., van der Hulst R; From the Department of Plastic Surgery, Maastricht University Medical Center, Maastricht, The Netherlands., van der Lei B; From the Department of Plastic Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.
Jazyk:	angličtina
Zdroj:	Aesthetic surgery journal [Aesthet Surg J] 2016 Sep; Vol. 36 (8), pp. 959-65. Date of Electronic Publication: 2016 Mar 14.
DOI:	10.1093/asj/sjw046
Abstrakt:	Background: The practice of prescribing vitamin E after surgery for scar prevention and treatment is widespread and increasingly popular among both the public and clinicians. However, very little evidence exists for this "ritual." Objectives: This review was undertaken to critically analyze the current literature about the effect of vitamin E on treating scars. Methods: The Cochrane, Medline, and PubMed databases were searched based on the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). The studies and levels of recommendation were graded according to the American Society of Plastic Surgeons (ASPS) criteria. Only prospective studies were included. Results: Only six studies met the inclusion criteria. Of these six included studies, three reported a significant improvement in the cosmetic appearance of scars when using vitamin E: one study used topical vitamin E in white children as monotherapy, and two studies used vitamin E in an adult population as combination therapy. The other three selected studies showed no significant improvement in scar appearance when using topical vitamin E as monotherapy. Two of the six included studies reported adverse events of vitamin E application: contact dermatitis and increased incidence of itching and rash. Conclusions: We conclude that there is not yet sufficient evidence that monotherapy with topical vitamin E has a significant beneficial effect on scar appearance to justify its widespread use. Further prospective studies with vitamin E monotherapy and/or combination therapy are warranted to draw better conclusions regarding the value of vitamin E in the management of scar healing. Level of Evidence: 2 Therapeutic. (© 2016 The American Society for Aesthetic Plastic Surgery, Inc. Reprints and permission: journals.permissions@oup.com.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu