A nanoporous gold membrane for sensing applications.

Autor:	Oo SZ; Optoelectronics Research Centre, University of Southampton, Southampton SO17 1BJ, UK., Silva G; Optoelectronics Research Centre, University of Southampton, Southampton SO17 1BJ, UK; Dipartimento di Ingegneria Industriale e dell'Informazione, Università degli Studi di Pavia, Pavia, Italy., Carpignano F; Optoelectronics Research Centre, University of Southampton, Southampton SO17 1BJ, UK; Dipartimento di Ingegneria Industriale e dell'Informazione, Università degli Studi di Pavia, Pavia, Italy., Noual A; Optoelectronics Research Centre, University of Southampton, Southampton SO17 1BJ, UK., Pechstedt K; Optoelectronics Research Centre, University of Southampton, Southampton SO17 1BJ, UK., Mateos L; Optoelectronics Research Centre, University of Southampton, Southampton SO17 1BJ, UK., Grant-Jacob JA; Optoelectronics Research Centre, University of Southampton, Southampton SO17 1BJ, UK., Brocklesby B; Optoelectronics Research Centre, University of Southampton, Southampton SO17 1BJ, UK., Horak P; Optoelectronics Research Centre, University of Southampton, Southampton SO17 1BJ, UK., Charlton M; School of Electronics and Computer Science, University of Southampton, Southampton SO17 1BJ, UK., Boden SA; School of Electronics and Computer Science, University of Southampton, Southampton SO17 1BJ, UK., Melvin T; Optoelectronics Research Centre, University of Southampton, Southampton SO17 1BJ, UK; School of Electronics and Computer Science, University of Southampton, Southampton SO17 1BJ, UK.
Jazyk:	angličtina
Zdroj:	Sensing and Bio-Sensing Research [Sens Biosensing Res] 2016 Mar; Vol. 7, pp. 133-140.
DOI:	10.1016/j.sbsr.2016.01.001
Abstrakt:	Design and fabrication of three-dimensionally structured, gold membranes containing hexagonally close-packed microcavities with nanopores in the base, are described. Our aim is to create a nanoporous structure with localized enhancement of the fluorescence or Raman scattering at, and in the nanopore when excited with light of approximately 600 nm, with a view to provide sensitive detection of biomolecules. A range of geometries of the nanopore integrated into hexagonally close-packed assemblies of gold micro-cavities was first evaluated theoretically. The optimal size and shape of the nanopore in a single microcavity were then considered to provide the highest localized plasmon enhancement (of fluorescence or Raman scattering) at the very center of the nanopore for a bioanalyte traversing through. The optimized design was established to be a 1200 nm diameter cavity of 600 nm depth with a 50 nm square nanopore with rounded corners in the base. A gold 3D-structured membrane containing these sized microcavities with the integrated nanopore was successfully fabricated and 'proof of concept' Raman scattering experiments are described.
Databáze:	MEDLINE
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