Therapeutic iron restriction in sepsis.

Autor: Xia Y; School of Basic Medical Sciences, Zhejiang University, Zhejiang, China., Farah N; Department of Pharmacology, Dalhousie University, Halifax, Canada., Maxan A; Department of Microbiology and Immunology, Dalhousie University, Halifax, Canada., Zhou J; Department of Microbiology and Immunology, Dalhousie University, Halifax, Canada; Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, Canada., Lehmann C; Department of Pharmacology, Dalhousie University, Halifax, Canada; Department of Microbiology and Immunology, Dalhousie University, Halifax, Canada; Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, Canada; Department of Physiology and Biophysics, Dalhousie University, Halifax, Canada.
Jazyk: angličtina
Zdroj: Medical hypotheses [Med Hypotheses] 2016 Apr; Vol. 89, pp. 37-9. Date of Electronic Publication: 2016 Feb 06.
DOI: 10.1016/j.mehy.2016.01.018
Abstrakt: Sepsis represents the systemic immune response to an infection. Mortality of sepsis slightly decreased over the past years, but due to the growing incidence, the absolute number of deaths still increases and belongs to the three most frequent causes of death worldwide. To date, there is no specific treatment for sepsis available yet. Iron is essential to both human beings and microbes and of great significance in many physiological and biochemical processes. Since iron is involved in the bacterial proliferation and immune dysregulation, we hypothesize that restricting host iron levels by application of iron chelators attenuates bacterial growth and improves the detrimental dysregulation of the systemic immune response in sepsis.
(Copyright © 2016 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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