Inflammation and Change in Body Weight With Antiretroviral Therapy Initiation in a Multinational Cohort of HIV-Infected Adults.

Autor:	Mave V; Johns Hopkins University-BJ Medical College Clinical Research Site, Pune, India Division of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland., Erlandson KM; Department of Medicine, University of Colorado Denver, Aurora., Gupte N; Johns Hopkins University-BJ Medical College Clinical Research Site, Pune, India Division of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland., Balagopal A; Division of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland., Asmuth DM; Department of Medicine, University California Davis, Sacramento., Campbell TB; Department of Medicine, University of Colorado Denver, Aurora., Smeaton L; Harvard T. H. Chan School of Public Health, Boston, Massachusetts., Kumarasamy N; Y. R. Gaitonde Center for AIDS Research and Education, Chennai, India., Hakim J; University of Zimbabwe, Harare., Santos B; Hospital Nossa Senhora de Conceição, Porto Alegre, Brazil., Riviere C; Les Centres GHESKIO, Port-Au-Prince, Haiti., Hosseinipour MC; University of North Carolina Project, Lilongwe, Malawi., Sugandhavesa P; Research Institute for Health Sciences, Chiang Mai, Thailand., Infante R; IMPACTA Peru, San Miguel., Pillay S; Durban International Clinical Research Site, Durban University of Technology, South Africa., Cardoso SW; STD/AIDS Clinical Research Laboratory, Instituto de Pesquisa Clinica Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil., Tripathy S; National AIDS Research Institute, Pune, India., Mwelase N; Department of Medicine, University of Witwatersrand, Johannesburg, South Africa., Berendes S; Malawi College of Medicine-Johns Hopkins University Research Project, Blantyre Liverpool School of Tropical Medicine, United Kingdom., Andrade BB; Unidade de Medicina Investigativa, Laboratório Integrado de Microbiologia e Imunorregulação, Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, and Instituto Brasileiro para a Investigação da Tuberculose, Fundação José Silveira, Salvador, Brazil., Thomas DL; Division of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland., Bollinger RC; Division of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland., Gupta A; Johns Hopkins University-BJ Medical College Clinical Research Site, Pune, India Division of Infectious Diseases, Johns Hopkins University, Baltimore, Maryland.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2016 Jul 01; Vol. 214 (1), pp. 65-72. Date of Electronic Publication: 2016 Mar 08.
DOI:	10.1093/infdis/jiw096
Abstrakt:	Background: Both wasting and obesity are associated with inflammation, but the extent to which body weight changes influence inflammation during human immunodeficiency virus infection is unknown. Methods: Among a random virologically suppressed participants of the Prospective Evaluation of Antiretrovirals in Resource-Limited Settings trial, inflammatory markers were measured at weeks 0, 24, and 48 after antiretroviral therapy (ART) initiation. Associations between both baseline and change in body mass index (BMI; calculated as the weight in kilograms divided by the height in meters squared) and changes in inflammation markers were assessed using random effects models. Results: Of 246 participants, 27% were overweight/obese (BMI, ≥ 25), and 8% were underweight (BMI < 18.5) at baseline. After 48 weeks, 37% were overweight/obese, and 3% were underweight. While level of many inflammatory markers decreased 48 weeks after ART initiation in the overall group, the decrease in C-reactive protein (CRP) level was smaller in overweight/obese participants (P = .01), and the decreases in both CRP (P = .01) and interleukin 18 (P = .02) levels were smaller in underweight participants. Each 1-unit gain in BMI among overweight/obese participants was associated with a 0.02-log10 increase in soluble CD14 level (P = .05), while each 1-unit BMI gain among underweight participants was associated with a 9.32-mg/L decrease in CRP level (P = .001). Conclusions: Being either overweight or underweight at ART initiation was associated with heightened systemic inflammation. While weight gain among overweight/obese persons predicted increased inflammation, weight gain among underweight persons predicted reduced inflammation. (© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu