Anti-inflammatory, analgesic and antioxidant activities of novel kyotorphin-nitroxide hybrid molecules.

Autor: Bi W; Department of Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, PR China; Second Hospital of HeBei Medical University, Shijiazhuang, HeBei 050000, PR China., Bi Y; Second Hospital of HeBei Medical University, Shijiazhuang, HeBei 050000, PR China., Gao X; Department of Chemistry, Michigan Technological University, Houghton, MI 49931, United States., Yan X; Department of Chemistry, Michigan Technological University, Houghton, MI 49931, United States., Zhang Y; Second Hospital of HeBei Medical University, Shijiazhuang, HeBei 050000, PR China., Xue P; Second Hospital of HeBei Medical University, Shijiazhuang, HeBei 050000, PR China., Bammert CE; Department of Biological Sciences, Michigan Technological University, Houghton, MI 49931, United States., Legalley TD; Marquette General Heart and Vascular Institute, Marquette, MI 49855, United States., Michael Gibson K; Section of Experimental and Systems Pharmacology, College of Pharmacy, Washington State University, Spokane, WA 99202, United States., Bi L; Department of Chemistry, Michigan Technological University, Houghton, MI 49931, United States., Wang JX; Department of Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, PR China.
Jazyk: angličtina
Zdroj: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2016 Apr 15; Vol. 26 (8), pp. 2005-13. Date of Electronic Publication: 2016 Mar 03.
DOI: 10.1016/j.bmcl.2016.02.086
Abstrakt: Mitochondrial oxidative damage contributes to a wide range of pathologies, including ischemia/reperfusion (I/R) injury, cardiovascular disorders and neurodegenerative diseases. Accordingly, protecting mitochondria from oxidative damage should possess therapeutic relevance. In the present study, we have designed and synthesized a series of novel kyotorphin-nitroxide hybrid molecules, and examined their free radical scavenging activities, in addition to their anti-inflammatory and analgesic activities. We have further characterized these compounds in a simulated I/R cellular model. Our findings suggest that the protective effects of kyotorphin-nitroxides partially reside in maintaining optimal mitochondrial function.
(Published by Elsevier Ltd.)
Databáze: MEDLINE
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