Chromatographic separation of germanium and arsenic for the production of high purity (77)As.

Autor: Gott MD; Department of Chemistry, University of Missouri, Columbia, MO 65211, United States., DeGraffenreid AJ; Department of Chemistry, University of Missouri, Columbia, MO 65211, United States., Feng Y; Department of Chemistry, University of Missouri, Columbia, MO 65211, United States., Phipps MD; Department of Chemistry, University of Missouri, Columbia, MO 65211, United States., Wycoff DE; Department of Chemistry, University of Missouri, Columbia, MO 65211, United States., Embree MF; University of Missouri Research Reactor Center, Columbia, MO 65211, United States., Cutler CS; University of Missouri Research Reactor Center, Columbia, MO 65211, United States., Ketring AR; University of Missouri Research Reactor Center, Columbia, MO 65211, United States., Jurisson SS; Department of Chemistry, University of Missouri, Columbia, MO 65211, United States. Electronic address: jurissons@missouri.edu.
Jazyk: angličtina
Zdroj: Journal of chromatography. A [J Chromatogr A] 2016 Apr 08; Vol. 1441, pp. 68-74. Date of Electronic Publication: 2016 Mar 02.
DOI: 10.1016/j.chroma.2016.02.074
Abstrakt: A simple column chromatographic method was developed to isolate (77)As (94±6% (EtOH/HCl); 74±11 (MeOH)) from germanium for potential use in radioimmunotherapy. The separation of arsenic from germanium was based on their relative affinities for different chromatographic materials in aqueous and organic environments. Using an organic or mixed mobile phase, germanium was selectively retained on a silica gel column as germanate, while arsenic was eluted from the column as arsenate. Subsequently, enriched (76)Ge (98±2) was recovered for reuse by elution with aqueous solution (neutral to basic). Greater than 98% radiolabeling yield of a (77)As-trithiol was observed from methanol separated [(77)As]arsenate [17].
(Copyright © 2016 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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