| Autor: |
Khalid P; Division of Biochemistry, Central Drug Research Institute, Lucknow, India., Chaturvedi S, Khan MM, Rastogi AK, Kundu B, Ahmad F, Mathur KB, Kidwai JR |
| Jazyk: |
angličtina |
| Zdroj: |
Acta diabetologica latina [Acta Diabetol Lat] 1989 Jul-Sep; Vol. 26 (3), pp. 203-9. |
| DOI: |
10.1007/BF02581386 |
| Abstrakt: |
The biologic activities of three synthetic analogues of CCK-4 (Trp-Met-Asp-Phe-NH2) in which (i) the C-terminal residue Phe was N-methylated (peptide I); (ii) the C-terminal Phe residue was N-methylated and Ser is substituted for Met in position 2 (peptide II); (iii) Pro was substituted for Trp in position 1 and the C-terminal amino nitrogen was methylated (peptide III), have been described. Peptides I and II have been found to inhibit the release of both insulin and glucagon, while peptide III was found to be a potent releasing agent for insulin and an inhibitor for glucagon. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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