Membrane Trafficking in Neuronal Development: Ins and Outs of Neural Connectivity.

Autor:	Winkle CC; Neuroscience Center and Curriculum in Neurobiology, University of North Carolina, Chapel Hill, NC, United States of America., Gupton SL; Neuroscience Center and Curriculum in Neurobiology, University of North Carolina, Chapel Hill, NC, United States of America; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC, United States of America; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, United States of America. Electronic address: sgupton@email.unc.edu.
Jazyk:	angličtina
Zdroj:	International review of cell and molecular biology [Int Rev Cell Mol Biol] 2016; Vol. 322, pp. 247-80. Date of Electronic Publication: 2016 Jan 06.
DOI:	10.1016/bs.ircmb.2015.10.003
Abstrakt:	During development, neurons progress through rapid yet stereotypical shape changes to achieve proper neuronal connectivity. This morphological progression requires carefully orchestrated plasma membrane expansion, insertion of membrane components including receptors for extracellular cues into the plasma membrane and removal and trafficking of membrane materials and proteins to specific locations. This review outlines the cellular machinery of membrane trafficking that play an integral role in neuronal cell shape change and function from initial neurite formation to pathway navigation and synaptogenesis. (Copyright © 2016 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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