| Autor: |
Devereaux ZJ; Department of Chemistry, Wayne State University , 5101 Cass Avenue, Detroit, Michigan 48202, United States., Reynolds CA; Department of Chemistry, Wayne State University , 5101 Cass Avenue, Detroit, Michigan 48202, United States., Fischer JL; Department of Chemistry, Wayne State University , 5101 Cass Avenue, Detroit, Michigan 48202, United States., Foley CD; Department of Chemistry, Wayne State University , 5101 Cass Avenue, Detroit, Michigan 48202, United States., DeLeeuw JL; Department of Chemistry, Wayne State University , 5101 Cass Avenue, Detroit, Michigan 48202, United States., Wager-Miller J; Gill Center for Biomolecular Science, Indiana University , 702 N. Walnut Grove Avenue, Bloomington, Indiana 47405, United States., Narayan SB; Detroit Medical Center: Detroit Hospital, 4201 St. Antoine Street, Detroit, Michigan 48201, United States., Mackie K; Gill Center for Biomolecular Science, Indiana University , 702 N. Walnut Grove Avenue, Bloomington, Indiana 47405, United States., Trimpin S; Department of Chemistry, Wayne State University , 5101 Cass Avenue, Detroit, Michigan 48202, United States.; Cardiovascular Research Institute, Wayne State University School of Medicine , 421 E. Canfield Street, Detroit, Michigan 48202, United States. |
| Abstrakt: |
Matrix-assisted ionization (MAI)-mass spectrometry (MS) eliminates the need for high voltage, a heat source, lasers, and compressed gases in the ionization process and uses minimal solvents in sample preparation, thus making MAI ideal for field-portable mass spectrometers. The broad applicability of MAI is demonstrated by simple, rapid, and robust positive and negative detection mode analyses of low and high mass compounds including some pesticides, dyes, drugs, lipids, and proteins (186 Da to 8.5 kDa) from various materials including urine, biological tissue sections, paper, and plant material on a low pumping capacity, single-quadrupole mass spectrometer. Different sample introduction methods are applicable, including the use of a pipet tip or glass melting point tube, allowing integration of sample preparation with sample introduction for increased analytical utility and ease of operation, even when sampling directly from surfaces. |
