Combining tract- and atlas-based analysis reveals microstructural abnormalities in early Tourette syndrome children.

Autor:	Wen H; State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, China.; Research Center for Brain-Inspired Intelligence, Institute of Automation, Chinese Academy of Sciences, Beijing, China., Liu Y; Department of Radiology, Beijing Children's Hospital, Capital Medical University, Beijing, China.; Beijing Key Lab of Magnetic Imaging Device and Technique, Beijing Children's Hospital, Capital Medical University, Beijing, China., Wang J; State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, China., Rekik I; Department of Radiology and BRIC, University of North Carolina at Chapel Hill, North Carolina., Zhang J; Department of Radiology, Beijing Children's Hospital, Capital Medical University, Beijing, China.; Beijing Key Lab of Magnetic Imaging Device and Technique, Beijing Children's Hospital, Capital Medical University, Beijing, China., Zhang Y; Department of Radiology, Beijing Children's Hospital, Capital Medical University, Beijing, China.; Beijing Key Lab of Magnetic Imaging Device and Technique, Beijing Children's Hospital, Capital Medical University, Beijing, China., Tian H; Department of Radiology, Beijing Children's Hospital, Capital Medical University, Beijing, China.; Beijing Key Lab of Magnetic Imaging Device and Technique, Beijing Children's Hospital, Capital Medical University, Beijing, China., Peng Y; Department of Radiology, Beijing Children's Hospital, Capital Medical University, Beijing, China.; Beijing Key Lab of Magnetic Imaging Device and Technique, Beijing Children's Hospital, Capital Medical University, Beijing, China., He H; State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, China.; Research Center for Brain-Inspired Intelligence, Institute of Automation, Chinese Academy of Sciences, Beijing, China.
Jazyk:	angličtina
Zdroj:	Human brain mapping [Hum Brain Mapp] 2016 May; Vol. 37 (5), pp. 1903-19. Date of Electronic Publication: 2016 Mar 01.
DOI:	10.1002/hbm.23146
Abstrakt:	Tourette syndrome (TS) is a neurological disorder that causes uncontrolled repetitive motor and vocal tics in children. Examining the neural basis of TS churned out different research studies that advanced our understanding of the brain pathways involved in its development. Particularly, growing evidence points to abnormalities within the fronto-striato-thalamic pathways. In this study, we combined Tract-Based Spatial Statistics (TBSS) and Atlas-based regions of interest (ROI) analysis approach, to investigate the microstructural diffusion changes in both deep and superficial white matter (SWM) in TS children. We then characterized the altered microstructure of white matter in 27 TS children in comparison with 27 age- and gender-matched healthy controls. We found that fractional anisotropy (FA) decreases and radial diffusivity (RD) increases in deep white matter (DWM) tracts in cortico-striato-thalamo-cortical (CSTC) circuit as well as SWM. Furthermore, we found that lower FA values and higher RD values in white matter regions are correlated with more severe tics, but not tics duration. Besides, we also found both axial diffusivity and mean diffusivity increase using Atlas-based ROI analysis. Our work may suggest that microstructural diffusion changes in white matter is not only restricted to the gray matter of CSTC circuit but also affects SWM within the primary motor and somatosensory cortex, commissural and association fibers. Hum Brain Mapp 37:1903-1919, 2016. © 2016 Wiley Periodicals, Inc. (© 2016 Wiley Periodicals, Inc.)
Databáze:	MEDLINE
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