A comparative evaluation of diffuse reflectance and Raman spectroscopy in the detection of cervical cancer.

Autor: Shaikh R; Chilakapati Laboratory, ACTREC, Kharghar, Navi Mumbai, 410210, India., Prabitha VG; Biophotonics Laboratory, National Centre for Earth Science Studies, Akkulam, Thiruvananthapuram, 695 031, Kerala, India., Dora TK; Tata Memorial Center, Radiation Oncology, ACTREC, Kharghar, Navi Mumbai, 410210, India., Chopra S; Tata Memorial Center, Radiation Oncology, ACTREC, Kharghar, Navi Mumbai, 410210, India., Maheshwari A; Tata Memorial Hospital, Gynecology Oncology, Parel, Mumbai, 400012, India., Deodhar K; Tata Memorial Hospital, Surgical Pathology, Cytopathology, Parel, Mumbai, 400012, India., Rekhi B; Tata Memorial Hospital, Surgical Pathology, Cytopathology, Parel, Mumbai, 400012, India., Sukumar N; Biophotonics Laboratory, National Centre for Earth Science Studies, Akkulam, Thiruvananthapuram, 695 031, Kerala, India., Krishna CM; Chilakapati Laboratory, ACTREC, Kharghar, Navi Mumbai, 410210, India., Subhash N; Sascan Meditech Pvt Ltd, Centre for Innovation in Medical Electronics, BMS College of Engineering, Basavanagudi, Bangalore, 560019, India.
Jazyk: angličtina
Zdroj: Journal of biophotonics [J Biophotonics] 2017 Feb; Vol. 10 (2), pp. 242-252. Date of Electronic Publication: 2016 Mar 01.
DOI: 10.1002/jbio.201500248
Abstrakt: Optical spectroscopic techniques show improved diagnostic accuracy for non-invasive detection of cervical cancers. In this study, sensitivity and specificity of two in vivo modalities, i.e diffuse reflectance spectroscopy (DRS) and Raman spectroscopy (RS), were compared by utilizing spectra recorded from the same sites (67 tumor (T), 22 normal cervix (C), and 57 normal vagina (V)). Data was analysed using principal component - linear discriminant analysis (PC-LDA), and validated using leave-one-out-cross-validation (LOOCV). Sensitivity, specificity, positive predictive value and negative predictive value for classification between normal (N) and tumor (T) sites were 91%, 96%, 95% and 93%, respectively for RS and 85%, 95%, 93% and 88%, respectively for DRS. Even though DRS revealed slightly lower diagnostic accuracies, owing to its lower cost and portability, it was found to be more suited for cervical cancer screening in low resource settings. On the other hand, RS based devices could be ideal for screening patients with centralised facilities in developing countries.
(© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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